Score
2
2012
pubmed
3 citations
Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys".
Criscione. Leoluca L
Key Findings
- Adipotide treatment led to weight loss and better insulin sensitivity in obese monkeys.
- The original mechanism proposed was apoptosis of blood vessels surrounding white adipose tissue.
- A commentary suggests the observed weight loss could be due to reduced food intake rather than direct fat loss.
Practical Outcomes
- For DIY biohackers, the data are not yet actionable; the peptideās effect on appetite versus fat tissue is unclear, and no safe dosing protocol is provided. More research is needed before considering adipotide for personal use.
Summary
A study showed that a peptide called adipotide made obese monkeys lose weight, and the original authors said it worked by killing blood vessels that feed white fat. However, a comment on the paper argues the weight loss might actually be because the monkeys ate less, not because the peptide directly destroyed fat tissue.
Abstract
A study reporting that a peptidomimetic adipotide reduces weight loss in obese monkeys by inducing apoptosis of blood vessels surrounding white adipose tissue may instead reflect a direct effect of adipotide on food consumption.
Study Information
Provider
pubmed
Year
2012
Date
2012-04-25T00:00:00.000Z
DOI
10.1126/scitranslmed.3003760
Citations
3
References
2