AOD 9604

AOD-9604, Anti-Obesity Drug 9604, Tyr-hGH177-191

A synthetic peptide analog of human growth hormone's lipolytic domain that promotes fat loss by stimulating lipolysis and inhibiting lipogenesis without growth effects.

Molecular Profile

Formula C₇₈H₁₂₃N₂₃O₂₃S₂

Mol. Weight 1815.1 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 300-500 mcg daily	300-500 mcg daily	High (95%)	SUB
Oral 1-10 mg daily	1-10 mg daily	Low (5%)	ORA
Intravenous (IV) 0.25-1 mg/kg	0.25-1 mg/kg	Complete (100%)	INT

How It Works

How It Works: AOD9604 mimics the lipolytic effects of human growth hormone by targeting fat metabolism without influencing growth or blood sugar levels.

Stimulates lipolysis: Promotes the breakdown of stored fat in adipose tissue.
Inhibits lipogenesis: Prevents the formation and accumulation of new fat.
Enhances fat oxidation: Increases the rate at which fat is burned for energy.
No effect on IGF-1 or insulin sensitivity: Avoids diabetogenic or growth-promoting side effects.

Pairs Well With

Latest Studies

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Utility 1

pubmed Dec 15, 2015

Simplifying and expanding the screening for peptides <2 kDa by direct urine injection, liquid chromatography, and ion mobility mass spectrometry.

Thomas. Andreas A; Görgens. Christian C; Guddat. Sven S; Thieme. Detlef D;...

The paper describes a new lab test that can spot tiny amounts of many performance‑enhancing peptides, including AOD‑9604, in urine. It shows the test is very sensitive, works over a useful range, and that the peptides stay stable when urine is kept at –20 °C.

pubmed Jul 24, 2015

Human sports drug testing by mass spectrometry.

Schänzer. Wilhelm W; Thevis. Mario M

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Utility 2

pubmed Nov 8, 2014

Detecting peptidic drugs, drug candidates and analogs in sports doping: current status and future directions.

Thevis. Mario M; Thomas. Andreas A; Schänzer. Wilhelm W

The article reviews how anti‑doping labs hunt down peptide drugs such as AOD‑9604. It explains that modern techniques like mass‑spectrometry, chromatography and immuno‑tests can spot these tiny molecules in tiny blood or urine samples, but there’s still a gap between what’s technically possible and what’s done every day.

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