Cibinetide, PHBSP, PH-BSP, Helix B surface peptide
An 11-amino acid peptide derived from erythropoietin, providing tissue protection, anti-inflammation, and neuroprotection without erythropoietic effects.
Swartjes. Maarten M; van Velzen. Monique M; Niesters. Marieke M; Aarts. Leon L; Brines. Michael M; D...
In rats with nerve injury, the peptide ARA‑290 reduced pain sensitivity (both mechanical and cold) for up to five months. The pain relief was strongest at doses of 10‑30 µg/kg and was linked to a drop in spinal microglia activation, a type of brain‑spine inflammation. No change was seen in astrocyte activity.
Swartjes. Maarten M; Niesters. Marieke M; Heij. Lara L; Dunne. Ann A; Aarts. Leon L; Hand. Carla Cer...
In mice, both ketamine and the peptide ARA290 can ease nerve‑pain, but they only work if a specific receptor called the innate repair receptor (IRR) is present. When that receptor is missing, neither drug helps with chronic pain, although ketamine still makes mice less sensitive to regular pain and causes noticeable side effects. ARA290, on the other hand, doesn’t cause those side effects.
van Rijt. Willem G WG; van Goor. Harry H; Ploeg. Rutger J RJ; Leuvenink. Henri G D HG
The paper says that giving a lot of regular EPO after a kidney transplant didn’t help the kidney and raised clot risks, but versions of EPO that don’t boost red blood cells (like ARA‑290) protected kidneys in animal studies without those side effects. However, there’s no solid human data yet, so it’s more of a future possibility than a current DIY protocol.
The study found that the peptide ARA 290, which mimics part of the hormone erythropoietin without causing blood clots, can protect muscle cells from death and inflammation when they are starved of oxygen in a lab setting. It also showed that the receptors these protective signals use are more abundant in the leg muscles of people with severe blood flow problems.
Scientists made tiny silica particles that carry both THC and a peptide called ARA290. In mouse tests, these particles reduced inflammation and gave long‑lasting relief from nerve pain. The system works by releasing the peptide where inflammation is high and letting THC stay in the tissue longer.
Chen. Hong H; Luo. Bangwei B; Yang. Xiaofeng X; Xiong. Jian J; Liu. Zongwei Z; Jiang. Man M; Shi. Ro...
In a rat model of multiple sclerosis, the short peptide ARA290 (a tiny version of the hormone EPO that doesn't boost blood cells) was given daily and it cut down disease severity, inflammation in the spinal cord, and the activity of immune cells that cause damage. It also nudged the immune system toward a calmer, anti‑inflammatory state.
Huang. Bo B; Jiang. Juntao J; Luo. Bangwei B; Zhu. Wen W; Liu. Yuqi Y; Wang. Zhishang Z; Zhang. Zhir...
In mouse models of lupus, the peptide ARA290 (a short piece of the hormone erythropoietin) lowered harmful auto‑antibodies, cut inflammation, protected the kidneys and did not cause extra red‑blood‑cell production. The work shows the peptide can act like erythropoietin’s anti‑inflammatory side without the blood‑building side effects.
Sanchis-Gomar. Fabian F; Perez-Quilis. Carme C; Lippi. Giuseppe G
The abstract explains that ARA‑290 is a newer drug that activates the same receptor as erythropoietin (Epo) but without boosting red blood cell production. This means it could protect tissues like the brain, heart, and kidneys while avoiding the side‑effects of traditional Epo therapy. Researchers are testing it in clinical trials for many conditions, but no specific dosing or home‑use protocol is provided.
Shokrzadeh. Mohammad M; Etebari. Mahmoud M; Ghassemi-Barghi. Nasrin N
The lab study shows that ARA290, a tiny peptide made from erythropoietin, can protect cells from the DNA damage and oxidative stress caused by the chemotherapy drug doxorubicin. In three different cell types, giving ARA290 before the drug lowered DNA breaks, reduced inflammation, and kept antioxidant enzymes working better.
O'Leary. Olivia E OE; Canning. Paul P; Reid. Emma E; Bertelli. Pietro M PM; McKeown. Stuart S; Brine...
In a mouse model of eye disease caused by poor blood flow, the peptide ARA‑290 (cibinetide) helped calm inflammation and protected blood‑vessel cells from damage. When the peptide was given together with a type of stem‑cell therapy, the cells repaired the damaged retina better than without the peptide. However, the study was done in animals and used a cell‑transplant approach, so it doesn’t give a ready‑to‑use protocol for people.
Al-Onaizi. Mohammed A MA; Thériault. Peter P; Lecordier. Sarah S; Prefontaine. Paul P; Rivest....
In a mouse model of early Alzheimer's, giving the peptide ARA 290 early on slowed the buildup of harmful brain proteins and helped the mice think better. The peptide worked by boosting a special type of blood immune cell that cleans up these proteins. However, the same treatment didn't help older mice with advanced disease, and it only worked when those cleaning cells were present.
Nairz. Manfred M; Haschka. David D; Dichtl. Stefanie S; Sonnweber. Thomas T; Schroll. Andrea A; A&#x...
Cibinetide, a drug that activates a special version of the erythropoietin receptor, lowered gut inflammation and helped mice with chemically‑induced colitis gain weight and survive longer by calming down immune cells.
Cerit. Hilâl H; Veer. Ilya M IM; Dahan. Albert A; Niesters. Marieke M; Harmer. Catherine J CJ;...
A single 2 mg dose of the peptide ARA290 was tested in healthy volunteers to see if it acts like an antidepressant. A week later, participants showed subtle changes in how they processed happy and negative emotions, but there were no mood improvements. Overall, the results don’t strongly support ARA290 as a mood‑boosting supplement.
Lois. Noemi N; Gardner. Evie E; McFarland. Margaret M; Armstrong. David D; McNally. Christine C; Lav...
A small Phase 2 study gave people with diabetic eye swelling (diabetic macular edema) a daily injection of the peptide cibinetide (also called ara‑290) for 12 weeks. The drug was safe, but it didn’t noticeably improve vision, retinal thickness, or eye sensitivity overall. Some participants reported feeling better in vision‑related quality‑of‑life surveys and showed modest improvements in eye fluid levels, blood sugar control, and kidney markers, but these effects were not consistent.
In lab tests, the short peptide ARA290 helped kidney cells avoid damage from the chemotherapy drug cisplatin. It did this by cutting down harmful oxidative stress, lowering inflammation signals, and stopping cells from dying through apoptosis. The study shows ARA290 can act like a protective shield for kidneys under toxic stress.
Dennhardt. Sophie S; Pirschel. Wiebke W; Wissuwa. Bianka B; Imhof. Diana D; Daniel. Christoph C; Kie...
In a mouse study, giving the EPO‑like peptide ARA‑290 (also called pHBSP) helped mice survive a severe kidney disease caused by Shiga toxin, mainly by lowering oxidative stress in the kidneys. It didn’t fix the kidney damage itself, and the research is still early, so it’s not a ready‑to‑use treatment for most people.
In rats, a type of nerve inflammation that causes pain (without obvious injury) can be created and measured. The peptide ARA290 was given to these rats and it lowered their pain responses to touch and heat. This shows ARA290 might help with certain kinds of chronic pain, but the work is still only in animals.
Yao. Ming M; Watanabe. Masaaki M; Sun. Sune S; Tokodai. Kazuaki K; Cerami. Anthony A; Brines. Michae...
In mice that received pancreas cell transplants, a peptide called Cibinetide (also known as ara-290) reduced early inflammation and helped the transplanted cells work better. When combined with a low dose of the immunosuppressant tacrolimus, it also extended the survival of the transplanted cells over the long term.
In mice, a synthetic peptide called Cibinetide (also known as ara-290) boosted bone density and blocked the formation of bone‑breaking cells. It worked both on its own and when given together with regular erythropoietin, suggesting it could protect against the bone loss that sometimes follows EPO use.
Mohtavinejad. Naser N; Hajiramezanali. Maliheh M; Akhlaghi. Mehdi M; Bitarafan-Rajabi. Ahmad A; Ghol...
Scientists made a version of the peptide ARA-290 that can be tagged with a radioactive metal (technetium-99m) so it lights up on a special heart scan (SPECT). In lab tests it stayed stable, stuck to low‑oxygen heart cells, and in rats it gathered in damaged heart tissue, suggesting it could help doctors spot heart attacks early.