Single chain peptide agonists of relaxin receptors.
Praveen. Praveen P; Kocan. Martina M; Valkovic. Adam A; Bathgate. Ross R; Hossain. Mohammed Akhter MA
Key Findings
- B7-33 is a single‑chain peptide that mimics the activity of natural relaxin hormones.
- It can activate relaxin family receptors (RXFP1‑RXFP4) in cellular and animal models.
- Early studies suggest it may influence processes like tissue remodeling and metabolism, but human data are lacking.
Practical Outcomes
- At this stage, B7-33 is mainly of scientific interest and not ready for DIY use. Biohackers should wait for human safety and dosage studies before considering it in any protocol.
Summary
Scientists have made a simpler version of the hormone relaxin called B7-33, which is just one chain of the original two-chain molecule. This new peptide can still activate the same receptors in cells and has shown some effects in lab and animal experiments, but no human trials or clear dosing guidelines are provided yet.
Abstract
There are seven human relaxin family peptides that have two chains (A and B) and three disulfide bonds. The target receptors for four of these peptides are known as relaxin family peptide receptors, RXFP1-RXFP4. Detailed structure-activity relationship (SAR) studies of relaxin family peptides have been reported over the years and have led to the design of new analogs with agonistic and antagonistic properties. This review briefly summarizes the SAR of human relaxin 2 (H2 relaxin) and human relaxin 3 (H3 relaxin) leading to the design and development of single-B-chain only agonists, B7-33 and peptide 5. The physiological functions of these new peptides agonists in cellular and animal models are also described.
Study Information
pubmed
2019
2019-01-11T00:00:00.000Z
10.1016/j.mce.2019.01.008
12
57