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BPC-157

Body Protection Compound-157, PL-14736, Pentadecapeptide BPC 157

A synthetic pentadecapeptide derived from human gastric juice that promotes tissue healing, angiogenesis, and cytoprotection across various organs.

Molecular Profile
Formula C62H98N16O22
Mol. Weight 1419 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Subcutaneous (SC)
150-375 mcg twice daily
SUB
Oral
100-500 mcg 1-2 times daily
ORA
Intramuscular (IM, animal)
6-150 mcg/kg
INT

How It Works

How It Works: BPC-157 facilitates tissue repair and protection by modulating multiple cellular pathways, including growth factor expression and vascular functions, contributing to its regenerative effects.

  • Growth Factor Upregulation: Stimulates production of VEGF, EGF, and increases growth hormone receptor expression in tissues.
  • Proangiogenic Effects: Activates VEGFR2-Akt-eNOS pathways to promote new blood vessel formation and improve blood flow.
  • Nitric Oxide Modulation: Influences NO pathways to support endothelial function and healing.
  • Collagen Synthesis Enhancement: Activates FAK-paxillin pathways to accelerate collagen formation and fibroblast activity.
  • Anti-Inflammatory Actions: Reduces inflammation by modulating inflammatory mediators and raising pain thresholds.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Clinical Trials

Unknown PHASE1 NCT02637284

PCO-02 - Safety and Pharmacokinetics Trial

PharmaCotherapia d.o.o.
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 3
pubmed Sep 28, 2025

BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on J&#xf3;zwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. <i>Pharmaceuticals</i> 2025, <i>18</i>, 185.

Sikiric. Predrag P; Seiwerth. Sven S; Skrtic. Anita A; Staresinic. Mario M; Strb...

The paper argues that BPC‑157 is a very safe peptide that helps the body heal by balancing blood‑vessel growth and nitric‑oxide activity. It says the peptide can protect nerves in animal models of Parkinson’s and Alzheimer’s, and even shows anti‑cancer effects, while not causing harmful new blood‑vessel growth.

pubmed Sep 28, 2025

Reply to Sikiric et al. BPC 157 Therapy: Targeting Angiogenesis and Nitric Oxide's Cytotoxic and Damaging Actions, but Maintaining, Promoting, or Recovering Their Essential Protective Functions. Comment on "J&#xf3;zwiak et al. Multifunctionality and Possible Medical Application of the BPC 157 Peptide-Literature and Patent Review. <i>Pharmaceuticals</i> 2025, <i>18</i>, 185".

J&#xf3;zwiak. Michalina M; Bauer. Marta M; Kamysz. Wojciech W; Kleczkowska. Patr...

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Utility 2
pubmed Aug 12, 2025

Regeneration or Risk? A Narrative Review of BPC-157 for Musculoskeletal Healing.

McGuire. Flynn P FP; Martinez. Riley R; Lenz. Annika A; Skinner. Lee L; Cushman....

BPC-157 is a lab-made peptide that has shown strong healing effects in animal studies, especially for tendons, muscles, and nerves. In people, only a handful of tiny studies have been done and they reported no side‑effects, but there’s no solid proof it works or is safe for regular use. Until bigger human trials are done, it should be treated as an experimental compound.

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