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Dihexa

N-(1-Oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)-L-isoleucinamide, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide, PNB-0408

An oligopeptide derived from angiotensin IV that binds to HGF and potentiates its activity at c-Met receptor, promoting neurogenesis and cognitive function.

Molecular Profile
Formula C27H44N4O5
Mol. Weight 504.67 g/mol
Sequence Gly-Glu-Pro-Pro...
Clinical Data Trials
Scientific Data Studies
Route
Oral
2 mg/kg/day (rats)
ORA
Intraperitoneal (IP)
0.5 mg/kg/day (rats)
INT
Intravenous (IV)
10 mg/kg (rats)
INT

How It Works

How It Works: Dihexa functions as an angiotensin IV analog that enhances the hepatocyte growth factor (HGF)/c-Met signaling pathway, promoting neuronal repair, synaptogenesis, and cognitive enhancement.

  • Binds with high affinity to HGF and potentiates its activity at the c-Met receptor.
  • Stimulates neurogenesis, dendritic arborization, spinogenesis, and synaptogenesis in the hippocampus.
  • Improves cognitive functions by enhancing synaptic connectivity and neuronal plasticity.
  • Acts synergistically with HGF to promote cellular motility, proliferation, and protection against neurodegeneration.

Pairs Well With

TB
TB-500
Systemic repair
Cu
GHK-Cu
Skin & collagen
KP
KPV
Anti-inflammatory
Ip
Ipamorelin
GH secretagogue

Latest Studies

Utility 1
pubmed Apr 11, 2022

Efficiently generate functional hepatic cells from human pluripotent stem cells by complete small-molecule strategy.

Pan. Tingcai T; Wang. Ning N; Zhang. Jiaye J; Yang. Fan F; Chen. Yan Y; Zhuang....

Scientists found that a mix of cheap chemicals, including the peptide dihexa, can turn stem cells into liver‑like cells in the lab without using expensive growth factors. This method works well for making lots of functional liver cells for research or therapy, but it isn’t a recipe you can use on yourself.

Utility 2
pubmed Nov 11, 2021

AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway.

Sun. Xiaojin X; Deng. Yang Y; Fu. Xinxin X; Wang. Siyu S; Duan. Rui R; Zhang. Yi...

In a mouse model of Alzheimer's, an oral peptide called Dihexa boosted a brain hormone (AngIV), improved memory in maze tests, and lowered brain inflammation by turning on the PI3K/AKT pathway. The benefits disappeared when the pathway was blocked, showing it’s likely the key mechanism.

Utility 2
pubmed Oct 8, 2021

Stem cell, Granulocyte-Colony Stimulating Factor and/or Dihexa to promote limb function recovery in a rat sciatic nerve damage-repair model: Experimental animal studies.

Weiss. Jessica B JB; Phillips. Cody J CJ; Malin. Edward W EW; Gorantla. Vijay S...

In rats with a cut sciatic nerve, giving a mix of stem cells, a growth factor (G‑CSF), or the peptide Dihexa helped the leg muscles work better after surgery. All the rats got their feeling back in about 8 weeks, but the groups that got stem cells plus Dihexa (or G‑CSF) showed noticeably better walking ability than the others.

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