DSIP

Emideltide, DSIP nonapeptide, Delta sleep-inducing peptide

A neuropeptide that induces delta sleep, reduces stress, modulates hormone release, and exhibits antioxidant effects in various physiological processes.

Molecular Profile

Formula C₃₅H₄₈N₁₀O₁₅

Mol. Weight 848.8 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Intravenous (IV) 25 nmol/kg	25 nmol/kg	Complete (100%)	INT
Subcutaneous (SC) 100-500 mcg	100-500 mcg	High (90%)	SUB
Intranasal 120 mcg/kg	120 mcg/kg	Moderate (65%)	INT

How It Works

How It Works: DSIP functions as a neuropeptide that promotes sleep and stress reduction by influencing hormonal pathways and neurological activity, though its exact mechanisms remain partially unclear.

Decreases basal corticotropin (ACTH) levels and blocks its release, reducing stress responses.
Stimulates the release of luteinizing hormone (LH) and somatotropin (growth hormone).
Enhances delta wave activity in EEG, promoting deeper sleep stages.
Exhibits antioxidant effects by activating endogenous protection mechanisms.
Modulates adrenergic receptors and interacts with serotonin and melatonin for circadian regulation.

Pairs Well With

Latest Clinical Trials

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Completed PHASE2 NCT05328154

MAGnesium Effect With ANtiosteoporotic Drugs

University Hospital, Clermont-Ferrand

INTERVENTIONAL

Updated Dec 15, 2025

Completed PHASE3 NCT01638403

Effects of BF2.649 in the Treatment of Excessive Daytime Sleepiness in Narcolepsy.

Bioprojet

INTERVENTIONAL

Updated Dec 15, 2025

Unknown PHASE1 NCT01239888

Oxytocin and Tibolone Adjuncts in Treatment Resistant Depression - A Pilot Study

The Alfred

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 2

pubmed Dec 5, 2025

Between Session Reliability of Traditional and Temporal Bilateral and Unilateral Dynamic Strength Index Calculations and Association With Sprint and Change of Direction Performance.

Tallis. Jason J; Bolt. Lee L; Morris. Rhys O RO; Suchomel. Timothy J TJ; Eustace...

Researchers tested how consistent different ways of measuring the Dynamic Strength Index (DSI) are across two testing sessions and whether those measurements predict sprint speed or change‑of‑direction ability. They found the traditional DSI method was a bit more reliable than newer, time‑specific versions, but overall reliability was only fair to moderate. The DSI numbers didn’t strongly link to sprint or agility performance, except the 100 ms version for the dominant leg showed a modest connection.

pubmed Jan 6, 2025

Domain-specific information preservation for Alzheimer's disease diagnosis with incomplete multi-modality neuroimages.

Xu. Haozhe H; Wang. Jian J; Feng. Qianjin Q; Zhang. Yu Y; Ning. Zhenyuan Z

The paper describes a new computer‑based method (called DSIP) that uses artificial intelligence to fill in missing brain scans and then diagnose Alzheimer's disease more accurately. It’s a technical advance for researchers who work with brain imaging data, not a health supplement or protocol that people can use at home.

Utility 2

pubmed Oct 8, 2024

<i>Pichia pastoris</i> secreted peptides crossing the blood-brain barrier and DSIP fusion peptide efficacy in PCPA-induced insomnia mouse models.

Mu. Xiaoxiao X; Qu. Lijun L; Yin. Liquan L; Wang. Libo L; Liu. Xiaoyang X; Liu....

Researchers made a version of the sleep‑boosting peptide DSIP that can cross the blood‑brain barrier by attaching a special carrier peptide. In mice made sleepy‑deprived with a drug, this new DSIP‑CBBBP improved sleep and balanced brain chemicals like serotonin, glutamate, dopamine and melatonin better than regular DSIP.

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