Detection of black market follistatin 344.
Reichel. Christian C; Gmeiner. Günter G; Thevis. Mario M
The study is about a lab method for detecting illegal black‑market foll ...
Follistatin 315
Activin-Binding Protein, FSH-Suppressing Protein, FST-315, FS-315
Follistatin-315 is the predominant circulating isoform of follistatin, a glycoprotein that binds and neutralizes TGF-β family members like myostatin and activin to promote muscle growth and regulate various physiological processes.
Molecular Profile
Formula
C1596H2543N461O523S43
Mol. Weight
34700 g/mol
Sequence
Gly-Glu-Pro-Pro...
| Route | |
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Subcutaneous (SC)
1-10 mcg/kg (animal studies)
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Oral
Not recommended
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Intravenous (IV)
1 mg/kg (animal studies)
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How It Works
How It Works: Follistatin-315 acts as a high-affinity antagonist to members of the TGF-β superfamily, primarily by binding to activins and myostatin, preventing their interaction with receptors and thereby regulating muscle growth, inflammation, and other cellular processes.
- Myostatin Inhibition: Binds to myostatin, inhibiting its activity and promoting skeletal muscle hypertrophy and hyperplasia.
- Activin Neutralization: Sequesters activin, blocking its signaling pathways involved in cell proliferation, differentiation, and apoptosis.
- TGF-β Superfamily Modulation: Interferes with other ligands like BMPs, influencing tissue development and repair.
- Circulatory Effects: As the main plasma isoform, it provides systemic regulation without strong cell surface binding.
Latest Clinical Trials
See All Clinical Trials
Not Yet Recruiting
NCT06290453
The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
Assiut University
OBSERVATIONAL
Updated Dec 15, 2025
Completed
PHASE3
NCT00564850
Efficacy and Safety Study of Pamoate of Triptorelin in Children With Precocious Puberty
Ipsen
INTERVENTIONAL
Updated Dec 15, 2025
Completed
NA
NCT03283462
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
Amazentis SA
INTERVENTIONAL
Updated Dec 15, 2025
Latest Studies
See All StudiesFollistatin Effects in Migration, Vascularization, and Osteogenesis <i>in vitro</i> and Bone Repair <i>in vivo</i>.
Fahmy-Garcia. Shorouk S; Farrell. Eric E; Witte-Bouma. Janneke J; Robbesom-van d...
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Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice.
Canali. Susanna S; Core. Amanda B AB; Zumbrennen-Bullough. Kimberly B KB; Merkul...
The study shows that a protein called activin B can raise the liver hormone hepcidin, which lowers iron levels during inflammation. The peptide follistatin‑315 blocks this effect, keeping hepcidin from spiking when the body is inflamed. The work was done in mouse liver cells and in mice given inflammatory triggers.