Central serous chorioretinopathy associated with high-dose follistatin-344: a retrospective case series.
Dağ. Umut U; Çağlayan. Mehtap M; Öncül. Hasan H; Alak...
Follistatin 344
FS-344, Activin-Binding Protein, FST344
Follistatin-344 is a 344-amino acid peptide that antagonizes myostatin and activin, promoting muscle growth, regeneration, and inhibiting muscle wasting.
Molecular Profile
Formula
C1656H2544N448O496S8
Mol. Weight
38006.785 g/mol
Sequence
Gly-Glu-Pro-Pro...
| Route | |
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Subcutaneous (SC)
10 mg/kg (animal studies)
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Intramuscular (IM)
Variable (gene therapy delivery in human trials)
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How It Works
How It Works: Follistatin-344 functions as a potent inhibitor of the TGF-β superfamily members, particularly myostatin and activin, by binding to them and preventing their interaction with cell surface receptors, thereby facilitating muscle growth and other regenerative processes.
- Binds directly to myostatin, blocking its inhibitory effects on muscle cell proliferation and differentiation.
- Antagonizes activin, which regulates follicle-stimulating hormone secretion and cellular processes like proliferation and apoptosis.
- Upregulates muscle hypertrophy and strength by removing negative growth regulators.
- May support wound healing and neuroprotection through modulation of inflammatory and growth factor pathways.
Latest Clinical Trials
See All Clinical Trials
Not Yet Recruiting
NCT06290453
The Regulatory Role of miRNA 27 Follistatin Like Protein-1 Gene in Multiple Scelerosis
Assiut University
OBSERVATIONAL
Updated Dec 15, 2025
Completed
NA
NCT03283462
Bioenergetics and Muscle Function Improvement With AMAZ-02 in Elderly Skeletal Muscle (ENERGIZE Trial)
Amazentis SA
INTERVENTIONAL
Updated Dec 15, 2025
Completed
PHASE3
NCT02901379
Effect of 80-mg Atorvastatin on Myocardial Edema
National Cardiovascular Center Harapan Kita Hospital Indonesia
INTERVENTIONAL
Updated Dec 15, 2025
Latest Studies
See All StudiesThe transgenic expression of human follistatin-344 increases skeletal muscle mass in pigs.
Chang. Fei F; Fang. Rui R; Wang. Meng M; Zhao. Xin X; Chang. Wen W; Zhang. Zaihu...
Scientists made pigs that produce extra human follistatin-344 just in their muscles. These pigs grew more muscle and less fat, mainly because their muscle fibers got bigger. The changes were linked to lower Smad2 activity and higher Akt activity, and the pigs showed no heart or reproductive problems.