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Proxofim, FOXO4 D-Retro-Inverso peptide
A synthetic D-retro-inverso peptide that disrupts FOXO4-p53 interaction, inducing selective apoptosis in senescent cells to reverse aging effects.
| Route | |
|---|---|
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Intraperitoneal (IP, animal)
5 mg/kg
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Subcutaneous (SC)
300-500 mcg
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How It Works: FOXO4-DRI acts as a senolytic by blocking the interaction between FOXO4 and p53 in senescent cells, enabling p53-mediated apoptosis and tissue rejuvenation.
Bourgeois. Benjamin B; Spreitzer. Emil E; Platero-Rochart. Daniel D; Paar. Margr...
Scientists discovered that the anti‑aging peptide FOXO4‑DRI sticks to a part of the p53 protein that’s usually floppy, and this binding helps kill old, senescent cells. The peptide works best when p53 is phosphorylated, and the study maps out exactly how the two molecules fit together.
Kong. Yu-Xiang YX; Li. Zhi-Shuai ZS; Liu. Yuan-Bo YB; Pan. Bo B; Fu. Xin X; Xiao...
Researchers found that a synthetic peptide called FOXO4-DRI can make scar‑forming cells (keloid fibroblasts) that are stuck in a senescent, aging‑like state die by pushing a key protein (p53) out of the cell nucleus. This reduces the number of stubborn scar cells in lab models, suggesting the peptide could help treat hard‑to‑heal scars.
Li. Yanqing Y; Zhang. Chi C; Cheng. Haicheng H; Lv. LinYan L; Zhu. Xinning X; Ma...
A study in old mice found that a short peptide called FOXO4-DRI can kill aging Leydig cells in the testicles, lower the harmful chemicals they release, and help sperm production improve. Treated mice had better sperm quality and more active spermatogenesis, suggesting the peptide might counter age‑related male fertility loss, but the work is still limited to animal experiments.