GHK-Cu

Copper Tripeptide-1, Glycyl-L-Histidyl-L-Lysine Copper, Prezatide Copper

A naturally occurring copper-binding tripeptide that promotes wound healing, collagen production, and anti-aging effects in skin and tissues.

Molecular Profile

Formula C₁₄H₂₂CuN₆O₄

Mol. Weight 401.91 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Topical 0.1-2% concentration in cream, applied daily	0.1-2% concentration in cream, applied daily	Low systemic (10%)	TOP
Subcutaneous (research) 1-5 mg daily	1-5 mg daily	High (95%)	SUB
Intraperitoneal (animal) 0.2-20 mg/kg/day	0.2-20 mg/kg/day	High (90%)	INT

How It Works

How It Works: GHK-Cu complexes with copper to modulate cellular signaling, enhancing tissue repair, reducing inflammation, and promoting regeneration across various systems.

Gene Expression Modulation: Regulates over 4,000 genes involved in anti-aging, antioxidant defense, and tissue remodeling.
Collagen and ECM Synthesis: Stimulates production of collagen, elastin, and glycosaminoglycans in fibroblasts.
Anti-Inflammatory and Antioxidant Effects: Suppresses pro-inflammatory cytokines and reactive oxygen species.
Angiogenesis and Wound Healing: Promotes blood vessel formation, nerve outgrowth, and accelerated healing.

Pairs Well With

Latest Clinical Trials

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Completed PHASE4 NCT05932732

Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatments in Adults of All Skin Types.

Austin Institute for Clinical Research

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 2

pubmed Dec 8, 2025

Golgi-targeted copper delivery strategy via enhancing copper-dependent proteins' activity for fascia regeneration.

Wang. Rui R; Xu. Yiru Y; Saiding. Qimanguli Q; Ling. Shifeng S; Yu. Jie J; Zhuan...

Scientists built a special delivery system that puts copper (using the GHK‑Cu peptide) straight into the cell's Golgi area, which boosts copper‑dependent enzymes like LOX. In rabbits with damaged fascia, this raised LOX activity, improved collagen alignment, and grew new blood vessels, helping the tissue heal faster.

pubmed Jul 25, 2025

An injectable hydroxyapatite microsphere filler loaded with GHK-Cu tripeptide for anti-Inflammatory and antioxidant.

Hu. Die D; Zhang. Xuexun X; Gong. Shiwen S; Ma. Wentao W; Cheng. Bo B; Yang. Jin...

Utility 3

pubmed Jul 2, 2025

Exploring the beneficial effects of GHK-Cu on an experimental model of colitis and the underlying mechanisms.

Mao. Shuzhen S; Huang. Jiahui J; Li. Junyan J; Sun. Fang F; Zhang. Qilian Q; Che...

In mice with chemically‑induced ulcerative colitis, giving the copper‑bound peptide GHK‑Cu helped the gut heal faster, reduced inflammation, and strengthened the barrier between gut cells. The benefits seemed to come from turning on a protein called SIRT1 and turning down a signaling pathway (STAT3) that drives inflammation.

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