GHRP-6

Growth Hormone Releasing Peptide-6, Growth hormone-releasing hexapeptide, His-D-Trp-Ala-Trp-D-Phe-Lys-NH2

A synthetic hexapeptide that stimulates growth hormone secretion by mimicking ghrelin and binding to GHS receptors in the pituitary gland.

Molecular Profile

Formula C₄₆H₅₆N₁₂O₆

Mol. Weight 873.0 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Subcutaneous (SC) 100-300 mcg	100-300 mcg	High (85%)	SUB
Intravenous (IV) 1 mcg/kg	1 mcg/kg	Complete (100%)	INT
Oral 300 mcg/kg	300 mcg/kg	Very Low (0.3%)	ORA

How It Works

How It Works: GHRP-6 acts as a ghrelin mimetic, binding to growth hormone secretagogue receptors to stimulate GH release from the pituitary, independent of GHRH pathways.

Receptor Activation: Binds to GHS-R1a receptors in the pituitary and hypothalamus, mimicking ghrelin.
Signal Transduction: Increases intracellular calcium and activates PKC and PI3K/Akt pathways.
GH Secretion: Triggers pulsatile release of growth hormone from somatotroph cells.
Additional Effects: Stimulates appetite and may enhance prolactin and cortisol secretion at higher doses.

Pairs Well With

Latest Studies

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Utility 1

pubmed Dec 1, 2025

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.

Zhao. Xiaotong X; Pan. Kai K; Li. Rui R; Liu. Meina M; Li. Duo D; Jia. Pingping...

Scientists made a gel that slowly releases the peptide GHRP‑6 and tested it in mice with sudden kidney damage. The gel boosted certain metabolites and turned on a cell‑growth pathway, helping kidney cells survive and recover better.

Utility 2

pubmed Oct 28, 2025

Aza-Isotryptophan: Synthesis, Pictet-Spengler Chemistry, Incorporation and Conformational Analysis in Peptides, and Activity in Modulators of the Cluster of Differentiation-36 Receptor.

Wei. Xiaozheng X; Mulumba. Mukandila M; Chemtob. Sylvain S; Ong. Huy H; Lubell....

Researchers made a special version of the amino acid tryptophan (aza‑isotryptophan) and put it into a peptide called GHRP‑6. The modified peptide showed it can bind to the CD36 receptor and may help calm inflammation linked to certain immune pathways. This is an early lab finding and not yet tested in people.

pubmed Sep 30, 2025

Assessing The Effectiveness of Growth Hormone Releasing Protein-6 in Improving Human Oocyte Maturation and Meiotic Progression in <i>In Vitro</i> Maturation Culture Media.

Ostadian. Caspian C; Hayati. Nasim N; Zahiri Sorouri. Ziba Z; Hosseini. Ahmad A

Error: Timeout.

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