Humanin

HN, S14G-Humanin

A mitochondrial-derived peptide that protects against apoptosis, oxidative stress, and has potential in neurodegenerative and metabolic diseases.

Molecular Profile

Formula C₁₁₉H₂₀₄N₃₄O₃₂S₂

Mol. Weight 2687.2 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Intraperitoneal (IP) 1-10 mg/kg	1-10 mg/kg	High (80%)	INT
Intravenous (IV) 0.5-5 mg/kg	0.5-5 mg/kg	Complete (100%)	INT
Subcutaneous (SC) 2-10 mg/kg	2-10 mg/kg	Moderate (70%)	SUB

How It Works

How It Works: Humanin acts as a cytoprotective peptide by binding to specific receptors and modulating intracellular signaling pathways to prevent cell death and reduce stress.

Receptor Binding: Interacts with formyl peptide receptor-like 1 (FPRL1) and IGFBP-3 to inhibit pro-apoptotic proteins like Bax.
Signaling Pathways: Activates JAK2/STAT3 and ERK1/2 pathways to promote cell survival and anti-inflammatory effects.
Mitochondrial Protection: Reduces reactive oxygen species (ROS) and stabilizes mitochondrial function.
Anti-Apoptotic Effects: Suppresses caspase activation and cytochrome c release from mitochondria.

Pairs Well With

Latest Clinical Trials

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Terminated PHASE4 NCT01310738

Efficacy and Safety Study of Drugs for Treatment of Visceral Leishmaniasis in Brazil

University of Brasilia

INTERVENTIONAL

Updated Dec 15, 2025

Completed PHASE1 NCT03144778

Durvalumab With or Without Tremelimumab in Treating Participants With Stage II-IVA Oropharyngeal Squamous Cell Cancer

M.D. Anderson Cancer Center

INTERVENTIONAL

Updated Dec 15, 2025

Unknown NCT04104958

IVF Outcome in Polycystic Ovary Syndrome Patients

Assiut University

OBSERVATIONAL

Updated Dec 15, 2025

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Latest Studies

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Utility 4

pubmed Nov 17, 2025

Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes.

Basereh. Aref A; Khoramipour. Karen K; Hosseini. Najmeh N; HajHosseini. Mahdieh...

A study in women with type‑2 diabetes showed that doing mixed cardio‑and‑strength workouts three times a week for eight weeks, plus taking 8 mg of astaxanthin daily, raised the body’s natural peptide humanin, improved antioxidant and anti‑inflammatory markers, and led to better blood sugar and cholesterol numbers. The combination was more effective than exercise or astaxanthin alone, suggesting a practical way to boost metabolic health and possibly longevity.

Utility 2

pubmed Nov 9, 2025

Insights into the Biomarker Potential of Humanin and Mots-c Expression and Telomere Length in Alzheimer's Disease.

Rodríguez-Esparragón. Francisco F; Cazorla-Rivero. Sara E SE; Torrealb...

The study found that the genetic messages (mRNA) for the mitochondrial peptides humanin and MOTS‑c are lower in people with Alzheimer’s disease, while the actual protein levels in blood don’t change much. This suggests the mRNA could be an early warning sign, but the research doesn’t give a clear way to use this information in everyday health hacks.

Utility 1

pubmed Nov 3, 2025

Serum mtDNA DAMP abundance, fragmentation and heteroplasmic variants associate with Acute Respiratory Failure outcome: A secondary analysis of study NCT00976833.

Daly. Grant T GT; Hartsell. Emily M EM; Pastukh. Viktor M VM; Roberts. Justin T...

Researchers looked at tiny pieces of mitochondrial DNA in the blood of people with severe lung problems. They found that very short DNA fragments are linked to higher death rates, and a specific genetic change in a humanin‑like gene (MT‑SHLP3) was tied to better survival. Other DNA changes were linked to worse outcomes, but the study doesn’t tell us how to use humanin as a supplement or therapy.

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