Highly potent growth hormone secretagogues: hybrids of NN703 and ipamorelin.
Hansen. T K TK; Ankersen. M M; Raun. K K; Hansen. B S BS
Key Findings
- Hybrid peptides with lysine mimetics and aromatic side chains showed very high GH‑secretagogue activity in vitro
- A single 50 nmol/kg dose in pigs produced a robust GH response in vivo
- Re‑adding certain C‑terminal groups to NN703 unexpectedly boosted potency
Practical Outcomes
- The work suggests that structural tweaks can make GH‑secretagogues like ipamorelin more powerful, but the specific hybrids aren’t available and lack human safety data, so they’re not ready for DIY use. Stick with established peptides and dosing protocols while monitoring future research for safer, effective variants.
Summary
Scientists created new hybrid peptides that mix parts of NN703 and ipamorelin, and these compounds triggered a strong growth‑hormone release in rat pituitary cells and in pigs when given at a single dose of 50 nmol/kg, showing they are more potent than the original molecules.
Abstract
A series of NN703 analogues with lysine mimetics combined with naphthyl- or biphenylalanine in the core has been prepared and tested in vitro in a rat pituitary cell based assay and subsequently in vivo in pigs in a single dose at 50 nmol/kg. Re-introduction of certain pharmacophores in the C-terminal of NN703, which were originally removed during optimisation for oral bioavailability, led to unexpectedly potent compounds in vitro as well as in vivo.
Study Information
pubmed
2001
2001-07-23T00:00:00.000Z
10.1016/s0960-894x(01)00345-6