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Ipamorelin

NNC 26-0161, Aib-His-D-2-Nal-D-Phe-Lys-NH2

Quick Stats
Studies 17
Trials 2
Overview Studies Clinical Trials
Score 2
2001 pubmed

The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats.

Andersen. N B NB; Malmlöf. K K; Johansen. P B PB; Andreassen. T T TT; Ørtoft. G G; Oxlund. H H

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Key Findings

  • Glucocorticoid (steroid) treatment reduced muscle strength and bone formation in adult female rats
  • Co‑administration of ipamorelin (100 µg/kg, three times daily) prevented the loss of muscle strength
  • Periosteal bone formation rate increased about four‑fold when ipamorelin was given with the steroid

Practical Outcomes

  • The results hint that ipamorelin might protect against steroid‑induced muscle and bone loss, but the data are from rats only. No human dosing or safety info is available yet, so it isn’t ready for a DIY protocol, though it could inform future clinical research.

Summary

In a rat study, giving the growth‑hormone‑releasing peptide ipamorelin alongside a strong steroid (methylprednisolone) stopped the steroid from weakening muscles and bone. The combo restored muscle strength and boosted bone‑building activity four‑fold compared to steroids alone.

Abstract

The ability of the growth hormone secretagogue (GHS) Ipamorelin to counteract the catabolic effects of glucocorticoid (GC) on skeletal muscles and bone was investigated in vivo in an adult rat model. Groups of 8-month-old female rats were injected subcutaneously for 3 months with GC (methylprednisolone) 9 mg/kg/day or GHS (Ipamorelin) 100 microg/kg three times daily, or both GC and GHS in combination. The maximum tetanic tension of the calf muscles was determined in vivo in a materials testing machine. The maximum tetanic tension was increased significantly, and the periosteal bone formation rate increased four-fold in animals injected with GC and GHS in combination, compared with the group injected with GC alone. In conclusion, the decrease in muscle strength and bone formation found in GC-injected rats was counteracted by simultaneous administration of the growth hormone secretagogue.

Study Information

Provider

pubmed

Year

2001

DOI

10.1054/ghir.2001.0239