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KP-10, Metastin (45-54), Kisspeptin-10 (human), KiSS-1
Kisspeptin-10 is a decapeptide that activates the KISS1R receptor to stimulate GnRH release, regulating the reproductive hormone axis and fertility.
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Intravenous (IV)
0.01-3 nmol/kg
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Subcutaneous (SC)
0.2-6.4 nmol/kg
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How It Works: Kisspeptin-10 primarily functions by binding to the KISS1 receptor on GnRH neurons in the hypothalamus, triggering the release of GnRH and subsequently stimulating the secretion of gonadotropins from the pituitary gland.
Zhao. Rongqian R; Nie. Li L; Shi. Yu Y; Jin. Lei L; Pan. Yiran Y; Zhang. Xinxin...
In mice fed a high‑fat diet, the hormone‑like peptide kisspeptin‑10 slowed liver cancer growth by turning down the activity of key enzymes that break down sugar. The study shows kisspeptin can counteract the cancer‑promoting effects of a fatty diet, at least in animal models.
Sridhar. Ananyaa A; Khan. Dawood D; Muthukumar. Rithiga R; Sampathkumar. Swetha...
In a mouse study, giving kisspeptin-10 twice daily for three weeks lowered body weight, blood sugar, and food intake in high‑fat‑diet females, making them look like mice on a normal diet. It also changed gut hormone‑producing cells and boosted the growth of insulin‑producing beta cells in the pancreas, without harming the cells.
Mills. Edouard G EG; Thurston. Layla L; Yang. Lisa L; Hunjan. Tia T; Phylactou....
In a study where healthy men and women received an IV dose of kisspeptin, their reproductive hormone (LH) shot up, but there was no change in how anxious they felt, nor in stress hormones, blood pressure, or heart rate. This suggests kisspeptin can boost reproductive signaling without causing anxiety.