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KPV

Lys-Pro-Val, α-MSH (11-13)

A tripeptide derived from alpha-melanocyte-stimulating hormone with potent anti-inflammatory, antimicrobial, and wound-healing properties.

Molecular Profile
Formula C16H30N4O4
Mol. Weight 342.43 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Oral
0.5-2 mg
ORA
Subcutaneous (SC)
200-500 mcg
SUB
Topical
0.1-1% in formulation
TOP

How It Works

How It Works: KPV acts as an anti-inflammatory peptide by mimicking alpha-MSH, primarily through binding to melanocortin receptors and modulating immune responses.

  • Interacts with MC1R and MC3R on immune cells to suppress inflammation.
  • Inhibits NF-ÎşB pathway, reducing pro-inflammatory cytokine production like TNF-α and IL-6.
  • Enhances PepT1 transporter-mediated uptake in the gut for targeted anti-inflammatory effects.
  • Exhibits direct antimicrobial activity against bacteria and fungi.

Latest Clinical Trials

Completed NA NCT00228943

The Role of Serotonin in Hot Flashes After Breast Cancer

Indiana University School of Medicine
INTERVENTIONAL
Updated Dec 15, 2025
Terminated PHASE2 NCT00550862

Study of INT 747 in Combination With URSO in Patients With Primay Biliary Cirrhosis (PBC)

Intercept Pharmaceuticals
INTERVENTIONAL
Updated Dec 15, 2025
Enrolling By Invitation NA NCT06846138

Enhancing the Efficacy and Tolerability of Metformin by add-on Polyherbal Formulation: a Gut Microbiome Study

Pauls Stradins Clinical University Hospital
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 2
pubmed Nov 13, 2025

Host defense peptides as a new drug lead to a strategy for inflammatory bowel disease.

Rodrigues. Júlia Morales JM; Ferreira Leal. Ana Paula AP; Buccini. Danieli...

This review says that natural tiny proteins called host‑defense peptides (like KPV) can kill gut bugs and calm down inflammation, so they might become safer treatments for ulcer‑like bowel diseases, but the paper only talks about the idea, not actual dosing or how to use them now.

pubmed Oct 30, 2025

Challenges in clinical nutrition research in Latin America: A narrative review.

Correia. Maria Isabel Toulson Davisson MITD; Papapietro. Karin K; Fuchs-Tarlovsk...

The article talks about why it’s hard to do good nutrition research in Latin America – not enough money, teamwork, or strong leadership. Because of these limits, hospitals struggle to spot and treat malnutrition early, which hurts patients and costs more. The paper suggests ways to fix these problems, but it doesn’t give any direct tips for using the peptide kpv or for personal health hacks.

Utility 3
pubmed Oct 1, 2025

Exploring the Role of Tripeptides in Wound Healing and Skin Regeneration: A Comprehensive Review.

Adnan. Siti Balqis SB; Maarof. Manira M; Fauzi. Mh Busra MB; Fadilah. Nur Izzah...

The review shows that tiny three‑amino‑acid peptides like KPV, GHK and KdPT can speed up skin healing by boosting cell movement, collagen build‑up, blood‑vessel growth and cutting inflammation, plus they can kill or stop bacteria. Some products already use these peptides in gels or creams, hinting they could be useful for faster wound repair, scar reduction, or even anti‑aging skin care, though exact dosages aren’t detailed yet.

Browse All Studies