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Lys-Glu-Asp-Ala, Tetrapeptide KEDA
A bioregulatory tetrapeptide that decondenses chromatin, modulates gene expression, and supports liver regeneration and immune function.
| Route | |
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Subcutaneous (SC)
100-300 mcg/day
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Oral
0.1-1 mg/kg (animal studies)
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How It Works: Livagen acts as a bioregulator by interacting with DNA to decondense chromatin and influence gene expression, promoting cellular rejuvenation and organ function.
Lezhava. Teimuraz T; Jokhadze. Tina T
The study shows that in cells taken from very old people, the DNA becomes more tightly packed (heterochromatin) with age, which can silence genes. Adding the peptide Livagen in the lab helped loosen this packing and reduced DNA damage caused by cobalt ions. However, the work was done only in cultured lymphocytes, not in living humans.
Khavinson. V Kh VKh; Lezhava. T A TA; Monaselidze. J G JG; Dzhokhadze. T A TA; D...
The study found that the synthetic peptide Livagen can change the way DNA is packaged in white blood cells from older people, making certain genes more active. It seems to loosen tightly packed DNA regions and turn on genes that usually get turned off with age, which could be linked to healthier cells.
Dzhokhadze. T A TA; Buadze. T Zh TZh; Dvalishvili. N A NA; Lezhava. T A TA
A lab study found that blood cells from older people still react to low‑dose radiation, and a peptide called Livagen seemed to help fix stress responses in those cells, but the work was done in test tubes and didn’t give any real‑world dosing or usage advice.