Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Melanotan-2

MT-II, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Quick Stats
Studies 3
Trials 100
Completed PHASE2 INTERVENTIONAL NCT00003127

S9720 Combination Chemotherapy in Treating Patients With Metastatic, Recurrent, or Refractory Endometrial Cancer

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells. PURPOSE: Phase II trial to study the effectiveness of combination chemotherapy in treating patients with metastatic, recurrent, or refractory endometrial cancer.

Detailed Description

OBJECTIVES: I. Evaluate the efficacy of paclitaxel and carboplatin with amifostine on progression free survival and overall survival in patients with metastatic or recurrent epithelial endometrial carcinoma not amenable to surgery or radiotherapy. II. Evaluate response (confirmed and unconfirmed partial response and complete response) rate to this regimen in this patient population. III. Assess the nature and degree of toxicity of this regimen in these patients. OUTLINE: Patients receive paclitaxel IV over 3 hours, then amifostine IV over 10 minutes, followed fifteen minutes later by carboplatin IV over 30-60 minutes on day 1. Courses repeat every 28 days. Treatment continues for 6 courses in the absence of disease progression. Patients are followed every 6 months for 2 years, then annually thereafter. PROJECTED ACCRUAL: A total of 35 to 50 patients will be accrued for this study.

Interventions

Name: amifostine trihydrate
Type: DRUG
Description: 740 mg/m2 IV, Day 1, q 28 days X 6 cycles
Name: carboplatin
Type: DRUG
Description: target AUC=6, IV Day 1, q 28 days X 6 cycles
Name: paclitaxel
Type: DRUG
Description: 175 mg/m2, IV, Day 1 q 28 days X 6 cycles

Primary Outcomes

Measure: Progression free survival
TimeFrame: 6 months
Description: from date of registration to date of first observation of progressive disease, deathe due to any cause, or early discontinuation of treatment.

Trial Information

NCT ID

NCT00003127

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE2

Sponsor

SWOG Cancer Research Network

Last Updated

December 15, 2025