Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Oxytocin

Pitocin, Syntocinon

Quick Stats
Studies 93
Trials 100
Completed NA INTERVENTIONAL NCT03928600

Labor Induction With a Combined Method (Pharmacologic and Mechanical): Randomized Controlled Trial

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Labor induction is a common pregnancy procedure worldwide. Both mechanical and pharmacologic agents are used for induction of labor. These agents reduce the incidence of cesarean delivery in women undergoing induction. Opposite to old studies of cervical ripening, some recent studies have shown promise in reducing labor time and risk of cesarean delivery with combination methods. The effectiveness of this procedure is of major clinical importance and has a large impact in our quotidian practice. The objective is to compare the effectiveness of a combined new method to current guidelines of our department

Detailed Description

We designed a randomized trial that will compare two groups: misoprostol-cervical Foley simultaneously and the current department guidelines (misoprostol alone/dinoprostone alone). Inclusion criteria: full-term (≥ 37 weeks of gestation), singleton, vertex-

Interventions

Name: Cervical Foley combined with Misoprostol
Type: COMBINATION_PRODUCT
Description: Placement of cervical Foley catheter along with application of vaginal misoprostol 25ug that will be repeated 4/4h until 150ug
Name: Dinoprostone 10mg insert OR
Type: DRUG
Description: Application for 24h of Dinoprostone 10mg insert
Name: Misoprostol
Type: DRUG
Description: Application of vaginal misoprostol 25ug 4/4h until 150ug

Primary Outcomes

Measure: Time to delivery
TimeFrame: 3 days
Description: Time to delivery

Trial Information

NCT ID

NCT03928600

Status

Completed

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Centro Hospitalar De São João, E.P.E.

Last Updated

December 15, 2025