Pre-operative Intranasal Oxytocin for Enhancing Bariatric-induced Diabetes Remission
Brief Summary
This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in obese adults with diabetes undergoing bariatric surgery. Subjects will be randomized to receive of intranasal oxytocin or placebo (8 units 3 times daily) for 8 weeks prior surgery. Study visits include screening to determine eligibility, CGM will be connected before and after oxytocin administration, and 1 year post surgery. blood tests including oral glucose tolerance test will be done and fat samples will be taken during surgery. The investigator's hypothesis is that oxytocin administration prior bariatric surgery can induce diabetes remission in patients with diabetes
Interventions
Primary Outcomes
Trial Information
NCT05207774
Unknown
INTERVENTIONAL
NA
Soroka University Medical Center
December 15, 2025