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Oxytocin

Pitocin, Syntocinon

Quick Stats
Studies 93
Trials 100
Unknown NA INTERVENTIONAL NCT05207774

Pre-operative Intranasal Oxytocin for Enhancing Bariatric-induced Diabetes Remission

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

This is a randomized, double blind, placebo-controlled study of the effects of intranasal oxytocin in obese adults with diabetes undergoing bariatric surgery. Subjects will be randomized to receive of intranasal oxytocin or placebo (8 units 3 times daily) for 8 weeks prior surgery. Study visits include screening to determine eligibility, CGM will be connected before and after oxytocin administration, and 1 year post surgery. blood tests including oral glucose tolerance test will be done and fat samples will be taken during surgery. The investigator's hypothesis is that oxytocin administration prior bariatric surgery can induce diabetes remission in patients with diabetes

Interventions

Name: Oxytocin
Type: DRUG
Description: 8 weeks intranasal oxytocin 24 units per day. 8 units prior each meal. 4units/0.1 ml per puff
Name: placebo
Type: DRUG
Description: 8 weeks intranasal placebo 0.6 ml per day. . 0.1 ml per puff

Primary Outcomes

Measure: Number of participants with diabetes remission 1 year post surgery
TimeFrame: 1 year post surgery
Description: HBA1C less then 6.5% without need for diabetes medication
Measure: Number of participants who improved their glycemic control
TimeFrame: 8 weeks
Description: increase in "Time in Range" by 10% and or decrease in HBA1C by 1 % 8 weeks from treatment
Measure: weight loss
TimeFrame: 8 weeks
Description: weight reduction - kg.
Measure: weight loss
TimeFrame: 1 year
Description: weight reduction - kg.
Measure: obesity
TimeFrame: 8 weeks
Description: change in waist circumference
Measure: obesity
TimeFrame: 1 year
Description: change in waist circumference

Trial Information

NCT ID

NCT05207774

Status

Unknown

Study Type

INTERVENTIONAL

Phases

NA

Sponsor

Soroka University Medical Center

Last Updated

December 15, 2025