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Oxytocin

Pitocin, Syntocinon

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Studies 93
Trials 100
Completed PHASE1 INTERVENTIONAL NCT03543917

Post-Stroke Improvement of Motor Function

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

Open-label clinical study where all new patients presenting with cerebrovascular accidents and consenting to treatment are given intravenously a new combination of medications. Patients are evaluated neurologically with NIHSS scores before treatment administration and at 1 month after the first treatment. Further evaluations at 6 months after treatment by NIHSS and Barthel scores are ongoing

Detailed Description

Patients with cerebrovascular accidents (CVA), ischemic (including those with hemorrhagic transformation), are given a new combination of medications which aims to improve neuronal survival, stimulate mitochondrial genesis and the formation of new synapses. This combination is given as an intravenous perfusion with a 2-hr duration and consists of vitamins B1, B6, B12, C, Actovegin, etc. Before treatment a NIHSS score is given. Each patient receives 3-4 such perfusions in 1 month and afterwards another NIHSS score is obtained. Patients are monitored afterwards and those who show improvements receive more such treatments, and new NIHSS and Barthel scores are obtained. Patients are grouped on the basis of the time interval between CVA occurence and first treatment: * Group 1: 0-35 days * Group 2: 36-100 days * Group 3: 101-360 days Improvement of motor function is compared using NIHSS scores between groups, and between literature and groups

Interventions

Name: Perfusion with New Combination Medication
Type: COMBINATION_PRODUCT
Description: Intravenous administration of Actovegin, vitamins B1, B6, B12, C, oxytocin/dexamethasone, calcium gluconate, etc in 250 ml normal saline administered during approximately 2 hours

Primary Outcomes

Measure: NIHSS differential
TimeFrame: 1 month after first administration of the combination
Description: score differential on the National Institutes of Health Stroke Scale(NIHSS); total score is evaluated before treatment and 1 month after first treatment; NIHSS scores range between 0 (best score) and 42 (worst score); the differential quantifies an improvement in neurological function

Trial Information

NCT ID

NCT03543917

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Fundatia Bio-Forum

Last Updated

December 15, 2025