RETRACTION: Rectal Misoprostol Versus Intravenous Oxytocin for Prevention of Postpartum Hemorrhage.
Key Findings
- The study claimed a benefit of rectal misoprostol versus IV oxytocin for postpartum hemorrhage.
- Statistical results (p‑values) for age, BMI, and weight were found to be incorrect.
- The authors could not provide raw data, leading to a retraction and the conclusions being deemed unreliable.
Practical Outcomes
- There are no actionable takeaways for biohackers or self‑experimenters. Do not base any health protocols on this retracted study, and look for validated research on oxytocin instead.
Summary
The paper that compared rectal misoprostol to IV oxytocin for preventing postpartum bleeding was retracted because the data and statistics were unreliable, so there’s nothing useful to apply from it.
Abstract
Nasr A, Shahin AY, Elsamman AM, Zakherah MS, Shaaban OM. Rectal Misoprostol Versus Intravenous Oxytocin for Prevention of Postpartum Hemorrhage. Int J Gynecol Obstet. 2009;105(3): 244-247. https://doi.org/10.1016/j.ijgo.2009.01.018. The above article, published online on 03 June 2015 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal Editor-in-Chief, Michael Geary; and John Wiley & Sons Ltd. UK. Concerns were raised by a third party that many of the reported p-value results for difference in age, BMI, and weight are incorrect. Additionally, the third party expressed concern that the inconsistent baseline results reported in Table 1 suggest that the study may not be a legitimate randomized controlled trial, as is claimed in the methods section. The authors responded to a request for clarification, but they were unable to provide their raw study data. Their responses to questions regarding their reported statistical results did not allay the concerns of the editorial team and publisher. As a result, the data and conclusions are considered unreliable, and therefore the article must be retracted. Speaking on behalf of the authors, A. Nasr does not agree with the decision to issue an retraction.
Study Information
pubmed
2025
2025-12-08T00:00:00.000Z
10.1002/ijgo.70737