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Oxytocin

Pitocin, Syntocinon

Quick Stats
Studies 93
Trials 100
2025 pubmed

Self-concept clarity and interoceptive updating in the rubber-hand illusion: A double replication study.

Klein. Willis W; Gregory. Amy J AJ; Krol. Sonia A SA; Bartz. Jennifer A JA

Key Findings

  • Lower self‑concept clarity predicts stronger rubber‑hand illusion in both synchronous and asynchronous conditions
  • The replication confirms the link between self‑concept clarity and bodily illusion susceptibility
  • Intranasal oxytocin did not affect embodiment of the rubber hand in this study

Practical Outcomes

  • For biohackers, this study suggests oxytocin isn’t useful for altering body perception or related performance outcomes. The findings mainly inform psychology research and have no direct health‑or‑longevity protocols to apply.

Summary

The research repeated a test showing that people with low self‑concept clarity are more likely to feel a fake rubber hand as their own, even when the visual‑tactile cues don’t match. The same link showed up in both synchronous and asynchronous stroking. Giving participants intranasal oxytocin did not change this illusion, so the peptide had no observable effect in this context.

Abstract

Prediction error minimization and embodied cognition theorists posit that abstract self-representations are predicated on models of the self as an embodied agent. While the view of continuity between conceptual and bodily self is common to several frameworks in psychology and cognitive science, empirical tests of this relationship are scant. However, a recent study by Krol et al., (see record 2020-26839-011) found that people low in self-concept clarity (SCC) were more vulnerable to the rubber-hand illusion-in particular, in the asynchronous stroking condition, where the illusion is unwarranted. This study provides preliminary evidence for an association between self-concept strength and vulnerability to illusions regarding the bodily self. Here we sought to replicate this finding in an existing study that assessed SCC and the rubber-hand illusion. Using linear mixed-effects modelling, we found that lower SCC was again associated with greater embodiment of the rubber hand in the asynchronous condition; moreover, we also observed this effect in the synchronous stroking condition, providing additional evidence for the role of SCC in vulnerability to bodily illusions. We discuss the implications of this finding for theories in social cognitive neuroscience. Finally, as the study we drew upon to test the replication effect involved the administration of intranasal oxytocin, we also took this opportunity to replicate a previously observed effect of oxytocin on embodiment of the rubber hand; this effect, however, did not replicate, although methodological difference may have played a role. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Study Information

Provider

pubmed

Year

2025

Date

2025-11-17T00:00:00.000Z

DOI

10.1037/cep0000387