Neurotrophic peptides incorporating adamantane improve learning and memory, promote neurogenesis and synaptic plasticity in mice.
Li. Bin B; Wanka. Lukas L; Blanchard. Julie J; Liu. Fei F; Chohan. Muhammad Omar MO; Iqbal. Khalid K; Grundke-Iqbal. Inge I
Key Findings
- Peripheral (outside the brain) dosing of P21 improved both short‑term and spatial memory in adult mice.
- P21 increased the number of new neurons forming in the dentate gyrus of the hippocampus.
- The newly formed neurons showed signs of maturing into functional brain cells.
Practical Outcomes
- The study shows that a simple peptide can enhance cognition and brain cell growth in mice, but it provides no human dosage, safety, or efficacy data. For biohackers, it suggests a promising direction for future research rather than an immediately usable supplement. Until human trials are done, it’s not advisable to try this peptide on its own.
Summary
A short peptide called P21, when injected into normal mice, made them learn faster and remember better. It also boosted the birth and growth of new brain cells in a region important for memory.
Abstract
Development of neurotrophic peptidergic drugs that can mimic neurotrophins and promote neurogenesis and maturation of newborn cells into mature functional neurons represents an exciting therapeutic opportunity for treatment of Alzheimer disease and other learning and memory disorders as well as enhancing cognition of normal individuals. Here we report the design of a peptidergic compound, Ac-DGGLAG-NH2, called P21, when administered peripherally, enhanced learning as well as both short-term and spatial reference memories of normal adult C57Bl6 mice. P21 induced enhancement of neurogenesis and maturation of newly born neurons in the granular cell layer and subgranular zone of the dentate gyrus.
Study Information
pubmed
2010
2010-06-30T00:00:00.000Z
10.1016/j.febslet.2010.06.025
50
45