Palmitoyl-dipeptide-6

Palmitoyl Dipeptide-6 Diaminohydroxybutyrate, Pal-Lys-Val-Dab

A synthetic signal peptide used in cosmetics to enhance skin repair, stimulate collagen production, and improve firmness and structure.

Molecular Profile

Formula C₃₁H₆₁N₅O₅

Mol. Weight 583.85 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Topical 10-100 ppm in formulations	10-100 ppm in formulations	Low (10%)	TOP

How It Works

How It Works: Palmitoyl Dipeptide-6 functions as a signal peptide that interacts with skin cells to promote anti-aging effects by supporting extracellular matrix components.

Stimulates fibroblasts to increase collagen and elastin synthesis
Strengthens the dermal-epidermal junction for better skin integrity
Improves skin hydration and reduces wrinkle appearance through enhanced protein production.

Pairs Well With

Latest Studies

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pubmed Jan 1, 2026

Tumor mRNA-lipid nanoparticles via chimeric nanobody-lipid co-assembly.

Zhu. Chuandong C; Wang. Jing J; Rahman. Md Mofizur MM; Zhang. Yun Y; Wang. Lixue...

The paper describes a new way to make cancer‑targeted mRNA nanoparticles by attaching a palmitoylated nanobody to the particle surface, avoiding PEG. It shows better delivery to HER2‑positive tumors and stronger anti‑tumor immune responses in mice, but it does not involve the skin‑care peptide palmitoyl‑dipeptide‑6 or give any advice that biohackers could use.

pubmed Dec 15, 2025

Palmitoylation of TRIM47 Regulates ATG16L1-Mediated Autophagy to Exacerbate Respiratory Distress Syndrome in Sepsis.

Wang. Qianlu Q; Deng. Longtian L; Cao. Yang Y; Yan. Shanshan S; Xing. Wei W

The study looks at how adding a fatty acid group (palmitoylation) to a protein called TRIM47 makes a type of lung injury worse in sepsis by blocking a cell recycling process called autophagy. It does not test or discuss the peptide palmitoyl‑dipeptide‑6, nor does it suggest any supplement or lifestyle changes.

pubmed Dec 9, 2025

A Novel Palmitoylation-Related Molecular Signature for Predicting and Therapeutically Targeting Alzheimer's Disease.

Miao. Xiuling X; Luo. Kaiyu K; Li. Yinglei Y; Zhou. Yang Y; Wei. Meng M; Zhang....

Scientists looked at gene activity related to a chemical process called palmitoylation and found a set of genes that can help predict Alzheimer's disease, but they didn’t test the peptide palmitoyl‑dipeptide‑6 itself, so there’s no direct advice for using it.

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