Use search to browse all 100+ peptides
Lys-Glu-Asp-Trp, KEDW
A synthetic tetrapeptide bioregulator that may support pancreatic function, glucose metabolism, and endocrine regulation in aging.
| Route | |
|---|---|
|
Subcutaneous (SC)
10 mg daily for 10-20 days
|
|
|
Intramuscular (IM)
10 mg daily for 10-20 days
|
|
|
Oral
10 mg daily for 10-20 days
|
How It Works: Pancragen penetrates cellular membranes and interacts with nuclear components, influencing gene transcription, cell differentiation, apoptosis, aging biomarkers, and metabolic regulation in pancreatic cells.
Khavinson. V Kh VKh; Durnova. A O AO; Polyakova. V O VO; Tolibova. G H GH; Linko...
A lab study found that the tiny peptide pancragen can boost the activity of genes that help pancreatic cells stay youthful and function properly, even in older cell cultures. This suggests it might help protect against diabetes and inflammation, but the work was done only in petri dishes, not in people.
Korkushko. O V OV; Khavinson. V Kh VKh; Shatilo. V B VB; Antonyk-Sheglova. I A I...
In older people with type‑2 diabetes, nighttime melatonin was much lower than in healthy peers. Giving the tetrapeptide pancragen lowered fasting blood sugar, improved glucose tolerance, and reduced insulin and insulin‑resistance markers, while people who didn’t get the peptide saw no change. The authors suggest that fixing melatonin‑related problems with pancragen might help older adults combat insulin resistance.
Khavinson. V Kh VKh; Gapparov. M M-G MM; Sharanova. N E NE; Vasilyev. A V AV; Ry...
The paper examined a naturally occurring four‑amino‑acid peptide (Lys‑Glu‑Asp‑Trp‑NH2) in developing animals and in a rat model of diabetes that mimics rapid aging. Researchers measured a bundle of metabolic markers linked to cell death (apoptosis) to see if the peptide had any protective or harmful effects. The study is very basic and does not provide dosing, safety, or clear performance benefits for humans.