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Retatrutide

LY3437943, LY-3437943

Quick Stats
Studies 83
Trials 32
Completed PHASE1 INTERVENTIONAL NCT05959096

A Study of LY3437943 in Healthy Participants With a High Body Mass Index

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

The study is conducted in two parts (Part A and B). The main purpose of this study is to look at the amount of the LY3437943 that gets into the blood stream and how long it takes the body to get rid of it when given subcutaneously (SC, under the skin) in the upper arm and thigh compared to the abdomen in healthy participants with high body mass index (BMI) in Part A. In Part B, the participants receive LY3437943 intravenously (IV, through a vein) where the safety and tolerability of LY3437943 are evaluated and information about any side effects experienced will be collected. For each participant, the total duration of the study will be approximately up to 157 days and 99 days for Part A and Part B, respectively.

Interventions

Name: LY3437943
Type: DRUG
Description: Administered SC
Name: LY3437943
Type: DRUG
Description: Administered IV

Primary Outcomes

Measure: Part A: Pharmacokinetics (PK): Area Under the Plasma Concentration Versus Time Curve From Zero to Infinity (AUC[0-∞]) of LY3437943
TimeFrame: Predose on Day 1 up to 43 days postdose (Part A)
Description: Part A: PK: AUC(0-∞) of LY3437943
Measure: Part A: PK: Maximum Concentration (Cmax) of LY3437943
TimeFrame: Predose on Day 1 up to 43 days postdose (Part A)
Description: Part A: PK: Cmax of LY3437943

Trial Information

NCT ID

NCT05959096

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Eli Lilly and Company

Last Updated

December 15, 2025