Selank

Selanc, TP-7

A synthetic heptapeptide with anxiolytic, neuroprotective, and immunomodulatory effects, modulating neurotransmitter systems without sedative side effects.

Molecular Profile

Formula C₃₃H₅₇N₁₁O₉

Mol. Weight 751.9 g/mol

Sequence Gly-Glu-Pro-Pro...

Clinical Data Trials

Scientific Data Studies

Route	Dosage	Bioavailability
Intranasal 200-900 mcg daily	200-900 mcg daily	Moderate (20%)	INT
Subcutaneous (SC) 200-500 mcg	200-500 mcg	High (95%)	SUB

How It Works

How It Works: Selank exerts its anxiolytic and nootropic effects by modulating key neurotransmitter systems and enzymatic activities in the brain, promoting balance without causing dependence or cognitive impairment.

GABAergic Modulation: Enhances GABA receptor activity similar to benzodiazepines but without sedation or tolerance.
Enkephalin Protection: Inhibits enzymes that degrade enkephalins, increasing endogenous opioid peptide levels.
Serotonin and Dopamine Regulation: Balances serotonin metabolism and dopamine signaling for mood stabilization.
BDNF Upregulation: Increases brain-derived neurotrophic factor expression for neuroprotection and cognitive enhancement.
Immunomodulation: Influences expression of inflammation-related genes to maintain immune balance.

Pairs Well With

Latest Clinical Trials

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Completed NA NCT05076045

Effects of PSAPs on Speech Processing

Rotman Research Institute at Baycrest

INTERVENTIONAL

Updated Dec 15, 2025

Completed NA NCT07196085

Neural Mechanisms and Efficacy of Imagery Rescripting for Fear of Failure

University of Social Sciences and Humanities, Warsaw

INTERVENTIONAL

Updated Dec 15, 2025

Completed NA NCT01770990

Trial of Telephone-based Psychotherapy for Depression With and Without Adjunctive Supportive Mail

Universitätsklinikum Hamburg-Eppendorf

INTERVENTIONAL

Updated Dec 15, 2025

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Latest Studies

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pubmed Aug 28, 2025

Efficiency in packed red blood management for brain tumor resection: multicentre prospective cohort study (TScoreBTR).

Contreras-Lopez. Laura L; Clavero. Fernando Iturri FI; Hurtado Restrepo. Paola A...

This study looked at how blood is prepared for brain tumor surgeries in Spain and found that most patients had blood units set aside, but only a small fraction actually needed a transfusion, showing a lot of waste. Women were more likely to be anemic before surgery and needed transfusions more often than men. The researchers say we need better rules to decide when to reserve blood to avoid inefficiency.

pubmed Aug 18, 2025

A study of the correlation between urinary perchlorate, nitrate, thiocyanate, and serum liver function indices.

Zhang. Wancheng W; Ling. Jianglong J; Lan. Lixiu L; Guo. Qiuhong Q; Ruan. Ye Y;...

This study looked at how three chemicals (perchlorate, nitrate, and thiocyanate) found in urine relate to liver health markers in a large U.S. population. It found complex, sometimes opposite, associations but did not test any peptide, supplement, or intervention that biohackers could use.

Utility 1

pubmed May 29, 2025

Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.

Chulanova. A A AA; Smakhtina. A M AM; Mal. G S GS; Bobyntsev. I I II; Smakhtin....

In a rat study, tiny doses of the peptide thymogen and its variants helped protect the liver from chemical damage, especially a version with an extra D‑alanine at the end, but bigger doses didn’t add extra benefit. The work was done by injecting the peptides directly into the animals, not by oral or other realistic routes for people.

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