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Semaglutide

Ozempic, Rybelsus, Wegovy

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Studies 78
Trials 100
Completed PHASE1 INTERVENTIONAL NCT05521256

A Research Study of a New Medicine NNC0113-6856 in Healthy Males

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

In this study NN0113-6856 will be given to humans for the first time. We will be looking into how safe different single doses of the new investigational product NNC0113-6856 is and we will measure its amount as well as the amount of specific parts of the new investigational product in blood. The study will look at the effects of different single doses of NNC0113-6856. This could either be as an oral dose (cohort 1 to 5) or one injection into the vein (intravenous \[IV\]-cohort). Participant will get the investigational product either as one or two tablets (oral dose in cohort 1 to 5) or as injection into the vein (IV cohort). The study will last for about 6-10 weeks (up to 14 weeks in case of rescheduling for stand-by participants).

Interventions

Name: NNC0113-6856
Type: DRUG
Description: Participants will receive NN0113-6856 orally or intravenously.
Name: Placebo
Type: DRUG
Description: Participants will receive matching placebo of NNC0113-6856 for each of the oral cohorts.

Primary Outcomes

Measure: Number of adverse events
TimeFrame: From time of dosing (day 1) until completion of the follow-up visit (Day 42)
Description: Measured as number of events.

Trial Information

NCT ID

NCT05521256

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Novo Nordisk A/S

Last Updated

December 15, 2025