Menu
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Semaglutide

Ozempic, Rybelsus, Wegovy

Quick Stats
Studies 78
Trials 100
Completed PHASE1 INTERVENTIONAL NCT06634927

Pharmacokinetic Similarity, Safety, and Immunogenicity of Semaglutide Injection and Ozempic ® Injection in Healthy Subjects.

View on ClinicalTrials.gov Updated Dec 15, 2025

Brief Summary

This study is a randomized, open-label, single-dose, parallel-controlled biosimilar comparison study comparing the pharmacokinetics, safety and immunogenicity of the investigational drug and the active comparator in healthy adult subjects. Eligible healthy participants will be screened and randomly assigned to the experimental group and the active comparator group at a ratio of 1:1 , semaglutide injection or Ozempic® injection 0.25mg abdominal subcutaneous injection will be given according to their groups. Follow-up for 5 weeks after administrtion. Studies included a screening period (up to 2 weeks), baseline, administration (single dose), and a follow-up period (5 weeks). The duration of the study will be approximately 7 weeks for a participant.

Interventions

Name: Ozempic®
Type: DRUG
Description: Participants will be given Ozempic ® injection 0.25mg abdominal subcutaneous injection.
Name: HDG1901
Type: DRUG
Description: Participants will be given HDG1901 injection 0.25mg abdominal subcutaneous injection.

Primary Outcomes

Measure: AUC0-inf
TimeFrame: -60minutes and 6, 12, 18, 24, 30, 36, 42, 48, 60, 72, 84, 96, 108, 120, 144, 336, 504, 672, 840 hours after administration
Description: Area Under the Concentration-time curve from time zero to infinite time
Measure: AUC0-t
TimeFrame: -60minutes and 6, 12, 18, 24, 30, 36, 42, 48, 60, 72, 84, 96, 108, 120, 144, 336, 504, 672, 840 hours after administration
Description: Area Under the Concentration-time curve from time zero to the last measurable concentration
Measure: Cmax
TimeFrame: -60minutes and 6, 12, 18, 24, 30, 36, 42, 48, 60, 72, 84, 96, 108, 120, 144, 336, 504, 672, 840 hours after administration
Description: Maximum concentration of the active substance in the blood plasma of participants during the observation period

Trial Information

NCT ID

NCT06634927

Status

Completed

Study Type

INTERVENTIONAL

Phases

PHASE1

Sponsor

Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.

Last Updated

December 15, 2025