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ACTH(4-10) analogue, Heptapeptide SEMAX
A synthetic heptapeptide analog of ACTH(4-10) that provides nootropic, neuroprotective, and cognitive-enhancing effects by modulating BDNF and neurotransmitter systems.
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Intranasal
0.015-0.050 mg/kg (approx. 200-1200 mcg)
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Intraperitoneal (animal)
0.015-0.060 mg/kg
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How It Works: Semax acts as a nootropic and neuroprotective agent by enhancing neurotrophic factors, modulating neurotransmitter systems, and influencing gene expression to support brain function and repair.
Kolbaev. S N SN; Sharonova. I N IN; Skrebitsky. V G VG
In rat brain slices, the peptide Semax (at a tiny lab dose) made hippocampal neurons fire calcium signals more often, but it didn't change how cerebellar cells responded to acid. This hints that Semax’s brain‑protective effects aren't due to blocking acid‑sensing calcium channels.
Asadullah. Asadullah A; Bajamal. Abdul Hafid AH; Parenrengi. Muhammad Arifin MA;...
In rats with a spinal cord injury, giving the peptide semax through the nose boosted levels of anti‑inflammatory proteins (IL‑4, IL‑10, IL‑13) compared to a salt solution. The effect was strongest a few hours after the injury and varied with injury severity. This shows semax can modulate inflammation in an acute injury model, but the study was done in animals, not people.
Giri. Sushil S; Chandra. Phool P
This review says that the peptide semax (along with other brain‑derived factors) can help protect brain cells by lowering oxidative stress, calming inflammation, keeping mitochondria healthy, and boosting synaptic plasticity, which are all important in diseases like Alzheimer’s and Parkinson’s. However, the paper is a broad overview and doesn’t give specific dosing or real‑world protocols, and it notes big hurdles like getting the peptide across the blood‑brain barrier and preventing it from breaking down.