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Sermorelin

GHRH (1-29), GRF 1-29 NH2, Sermorelin acetate

A synthetic 29-amino acid analog of growth hormone-releasing hormone that stimulates pituitary gland to release growth hormone.

Molecular Profile
Formula C149H246N44O42S
Mol. Weight 3357.9 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Intravenous (IV)
1 mcg/kg
INT
Subcutaneous (SC)
30 mcg/kg daily
SUB

How It Works

How It Works: Sermorelin acts as an agonist at the growth hormone-releasing hormone (GHRH) receptor in the anterior pituitary, mimicking natural GHRH to stimulate the pulsatile release of growth hormone.

  • Receptor Binding: Binds to GHRH receptors on somatotroph cells, activating G-protein-coupled receptors.
  • Signal Transduction: Increases intracellular cAMP via adenylate cyclase, leading to protein kinase A activation.
  • GH Secretion: Promotes transcription of GH gene and pulsatile secretion of growth hormone.
  • Feedback Regulation: Subject to negative feedback by somatostatin, preventing overdose and maintaining physiological rhythms.

Latest Clinical Trials

Withdrawn PHASE2 NCT02931474

Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current Insomnia

National Institute of Nursing Research (NINR)
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT00608023

TH9507 Extension Study in Patients With HIV-Associated Lipodystrophy

Theratechnologies
INTERVENTIONAL
Updated Dec 15, 2025
Completed PHASE2 NCT01264497

Safety Study of TH9507 in Subjects With Stable, Type 2 Diabetes

Theratechnologies
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 2
pubmed Oct 20, 2025

Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.

Uçaktürk. Ebru E; Nemutlu. Emirhan E

Scientists created a super‑sensitive urine test that can spot growth‑hormone‑releasing peptides like sermorelin at very low levels (0.5 ng/mL). The method uses tiny‑scale liquid chromatography and high‑resolution mass spectrometry, and it meets anti‑doping lab standards.

Utility 1
pubmed Oct 9, 2025

Growth hormone - releasing hormone antagonists induce autophagy in cancer cells.

Sigdel. Madan M; Fakir. Saikat S; Sarker. Md Matiur Rahman MMR; Barabutis. Nekta...

A lab study found that a peptide that blocks growth‑hormone‑releasing hormone (GHRH) can trigger the cell‑clean‑up process called autophagy in certain cancer cells that have GHRH receptors, but it does nothing in cells without those receptors.

Utility 1
pubmed Apr 1, 2025

Growth Hormone-Releasing Hormone Antagonists Increase Radiosensitivity in Non-Small Cell Lung Cancer Cells.

Gesmundo. Iacopo I; Pedrolli. Francesca F; Giglioli. Francesca Romana FR; Jazaj....

Scientists found that drugs that block the hormone that normally tells the body to release growth hormone can make lung cancer cells more vulnerable to radiation in lab dishes, but this research used special lab compounds, not the growth‑hormone‑releasing peptide sermorelin, and it’s far from any real‑world self‑experiment or treatment plan.

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