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Thymosin-alpha-1

Thymalfasin, Zadaxin, Thymosin α1

A synthetic 28-amino acid peptide that enhances immune function by modulating T-cell activity, used for viral infections and immunodeficiencies.

Molecular Profile
Formula C129H215N33O55
Mol. Weight 3108.3 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Subcutaneous (SC)
1.6 mg twice weekly
SUB
Intravenous (IV)
0.8-1.6 mg
INT

How It Works

How It Works: Thymosin Alpha-1 acts as an immunomodulator by enhancing the function of the immune system, particularly T-cells, to fight infections and restore immune balance.

  • Promotes T-cell maturation and differentiation, increasing the production of Th1 cytokines like IL-2 and IFN-gamma.
  • Enhances antigen presentation by dendritic cells and macrophages.
  • Modulates cytokine and chemokine production to reduce inflammation and prevent apoptosis in immune cells.
  • Stimulates natural killer cell activity and antibody responses.

Latest Clinical Trials

Unknown NCT06024356

Neoadjuvant Chemoradiotherapy Combined With PD-1 Inhibitor and Thymalfasin for Locally Advanced Mid-low Rectal Cancer

Beijing Friendship Hospital
OBSERVATIONAL
Updated Dec 15, 2025
Completed PHASE3 NCT02867267

The Efficacy and Safety of Ta1 for Sepsis

Sun Yat-sen University
INTERVENTIONAL
Updated Dec 15, 2025
Not Yet Recruiting NA NCT06607926

Neoadjuvant With Tα1 Plus Immuno-chemotherapy for Resectable NSCLC

Xuanwu Hospital, Beijing
INTERVENTIONAL
Updated Dec 15, 2025
View All Clinical Trials

Latest Studies

Utility 3
pubmed Nov 27, 2025

Aging and Thymosin Alpha-1.

Simonova. Maria A MA; Ivanov. Igor I; Shoshina. Natalia S NS; Komyakova. Alina M...

Thymosin alpha-1 is a natural peptide made by the thymus that can boost the aging immune system. Studies show it helps the body make more T‑cells, improves vaccine responses in older people, and reduces chronic inflammation. A new hybrid drug that combines it with TNF‑alpha looks promising but is still experimental.

Utility 3
pubmed Oct 14, 2025

Thymosin α1 alleviates pulpitis by inhibiting ferroptosis of dental pulp cells.

Wu. Jie J; Gong. Qimei Q; Liu. Wenxuan W; Chen. Aijia A; Liao. Zekai Z; Huang. Y...

The study shows that the peptide thymosin‑alpha‑1 can protect dental pulp cells from a type of cell death called ferroptosis, which helps reduce inflammation and tissue damage in tooth pulpitis. In lab‑grown cells and rat teeth, adding thymosin‑alpha‑1 boosted protective proteins (like GPX4) and lowered inflammatory markers, suggesting it could be a useful treatment for painful tooth pulp inflammation.

Utility 1
pubmed Sep 15, 2025

Thymosin α1 Combined With 2HRZE/4HR Regimen as a Potential Treatment of Pulmonary Tuberculosis: An Analysis of Immune Function, Pulmonary Function and Inflammatory Response.

Wu. Guofeng G; Sun. Xuelian X

Adding the immune‑boosting peptide thymosin‑alpha‑1 to the standard 6‑month TB drug regimen helped patients clear the infection faster, breathe better, and showed better immune and inflammation markers, without adding extra side effects.

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