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Ac-SDKP, Goralatide, Seraspenide
A tetrapeptide fragment of thymosin beta-4 that inhibits inflammation, reduces fibrosis, and regulates hematopoietic stem cell proliferation.
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Intravenous (IV)
0.25-2.5 pmol/kg/min (infusion, human research)
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Subcutaneous (SC)
1.6 mg/kg/day (animal models)
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How It Works: Thymosin Beta-4 Fragment (Ac-SDKP) functions as an anti-inflammatory and anti-fibrotic agent by modulating key cellular pathways, primarily through inhibition of angiotensin-converting enzyme and stem cell regulation.
Manly. Lester S LS; Roberts. Anne M AM; Beckman. Joseph S JS; Roberts. Blaine R...
The paper describes a fancy mass‑spectrometry technique that can read the exact sequence and tiny chemical changes of small proteins, including thymosin‑beta‑4, but it doesn’t give any advice on how to use the peptide for health or performance.
Delcourt. Vivian V; Garcia. Patrice P; Chabot. Benjamin B; Aber. Nina N; Pescher...
The researchers measured the natural amount of thymosin‑beta‑4 (TB4) in horse blood and found it’s about the same no matter the horse’s sex, age, or breed. They also discovered that if blood isn’t separated from cells and is kept at 4 °C, TB4 levels rise quickly because cells break open. Finally, they showed they can spot a synthetic TB4 product in a horse’s plasma after just one dose by looking for a tiny impurity that only shows up in lab‑made versions.
Yoon. Hyung Joon HJ; Oh. Young Lim YL; Ko. Eun-Ji EJ; Kang. Ahyun A; Eo. Wan Kyu...
The study shows that thymosin‑beta‑4 and its short fragment peptides make ovarian cancer cells move, invade, and grow faster, likely by raising a protein called RACK‑1. For people experimenting with peptides, this suggests that using thymosin‑beta‑4 could potentially promote cancer cell activity, not improve health.