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Tripeptide-1

GHK, Glycyl-L-Histidyl-L-Lysine

A synthetic tripeptide that binds copper to promote collagen synthesis, wound healing, and anti-aging effects in skin and tissues.

Molecular Profile
Formula C14H24N6O4
Mol. Weight 340.4 g/mol
Sequence Gly-Glu-Pro-Pro...
Route
Topical
0.1-2% in formulations
TOP
Intraperitoneal (IP)
1-10 mg/kg (animal studies)
INT

How It Works

How It Works: Tripeptide-1 (GHK) works by forming a complex with copper ions (GHK-Cu), which activates regenerative processes in tissues, particularly in skin repair and anti-aging.

  • Copper Binding: Chelates copper to enhance stability and cellular delivery.
  • Matrix Remodeling: Stimulates synthesis of collagen, elastin, and proteoglycans.
  • Angiogenesis Promotion: Increases blood vessel formation and growth factor expression.
  • Anti-Inflammatory and Antioxidant: Reduces inflammation and protects against oxidative stress.

Latest Clinical Trials

Completed NA NCT06125730

A Single-Group Study to Evaluate the Effects of an Eyelash Serum on Improving Eyelash Growth

Dime Beauty Co.
INTERVENTIONAL
Updated Dec 15, 2025
Unknown NA NCT05048407

Sirius in Gynaecological Laparoscopic Surgery

Precision Robotics (Hong Kong) Limited
INTERVENTIONAL
Updated Dec 15, 2025
Completed NA NCT05940675

Generation Healthy Kids: A Cluster-randomized Trial of a Multi-component, Multi-setting Intervention

University of Copenhagen
INTERVENTIONAL
Updated Dec 15, 2025
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