Recruiting
NA
INTERVENTIONAL
NCT06590623
The Effect of Acute Exogenous Oral Ketone Supplementation on Immune Cells Function and Immune Cells Histone Β-hydroxybutyrylation
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
To conduct a single-arm pilot study to determine how acute ingestion of an exogenous ketone monoester supplement alters the histone lysine β-hydroxybutyrylation and immune function in healthy human monocytes and lymphocytes.
Interventions
Name:
Ketone Monoester (KE)
Type:
DIETARY_SUPPLEMENT
Description:
Participants will receive an exogenous ketone supplement (KetoneAid KE4) in a fasted state in the morning, at a dosage of 0.75 g/kg of body weight.
Primary Outcomes
Measure:
β-hydroxybutyrylation of histone in human immune cells using Western blotting
TimeFrame:
Before (fasted state) and 2 hours after the consumption of the exogenous ketone supplement.
Description:
The β-hydroxybutyrylation of histones in human monocytes and lymphocytes will be assessed before and 2 hours after the consumption of an exogenous ketone supplement. Protein samples will be collected from the cells, and the levels of histone β-hydroxybutyrylation will be quantified using Western blotting.
Trial Information
NCT ID
NCT06590623
Status
Recruiting
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
University of British Columbia
Last Updated
December 15, 2025