Unknown
NA
INTERVENTIONAL
NCT01626911
Continuous Regional Arterial Infusion of Low Molecular Weight Heparin in Patients With Severe Acute Pancreatitis
View on ClinicalTrials.gov
Updated Dec 15, 2025
Brief Summary
Our animal studies found that continuous regional arterial infusion (CRAI in the celiac trunk) of low molecular weight heparin (LMWH) could alleviate inflammation, improve global hemodynamics and restore organ function in a porcine model of severe acute pancreatitis (SAP,unpublished). In this study, the investigators aim to evaluate the effects of CRAI of LMWH in the treatment of SAP patients. The investigators suppose CRAI could help improve the outcomes of these patients.
Interventions
Name:
Continuous regional arterial infusion of low molecular weight heparin in celiac trunk
Type:
PROCEDURE
Description:
Put a catheter to the celiac trunk through interventional technique. The approach to celiac trunk was via a femoral artery approach.The tip of the arterial catheter (4F) was placed in celiac trunk which could perfuse the pancreas.After that, continuous infusion of low molecular weight heparin through the catheter will be applied during the first 5 days after placement.
Name:
General treatment
Type:
OTHER
Description:
Include fluid resuscitation, percutaneous drainage if needed, antibiotics,organ support, etc.
Primary Outcomes
Measure:
coagulation related complications
TimeFrame:
14 days after the placement of celiac trunk catheter
Description:
bleeding for the most
coagulative parameters
Measure:
Pancreatic infection
TimeFrame:
28 days
Description:
Trial Information
NCT ID
NCT01626911
Status
Unknown
Study Type
INTERVENTIONAL
Phases
NA
Sponsor
Nanjing University School of Medicine
Last Updated
December 15, 2025