[Effect of vilon on neuroendocrine status and sexual function of old male rats].
Kudriavtseva. T A TA; Zaĭchenko. I N IN; Efremov. O M OM; Baĭramov. A A AA; Grigor'ev. E I EI; Ryzhak. G A GA
Key Findings
- Vilon at 50 µg/rat improved sexual function in aged male rats
- It altered neuroendocrine hormones: increased LH and ACTH, markedly reduced prolactin
- It changed hypothalamic neurotransmitter levels, suggesting multiple pathways
Practical Outcomes
- The study hints that Vilon could help age‑related sexual decline, but it’s only been tested in rats. No human dosing or safety data exist, so biohackers should wait for clinical trials before trying it.
Summary
In old male rats, a small daily dose of the dipeptide Vilon (50 µg per rat) boosted sexual activity and changed several brain and blood hormones linked to sexual health, especially lowering the age‑related rise in prolactin. The effects seem to come from a mix of hormone and neurotransmitter changes rather than one single factor.
Abstract
The hypogonadal status of hemigonadectomised male rats has been choseh as a model of age-related sexual function decline in animals. The effect of dipeptide Vilon on parameters of sexual function and neuroendocrine status was studied. The results showed that regular introduction of Vilon in a dose of 50 microg per rat activates sexual function in old male rats. The obtained data confirm that Vilon significantly affects neuroendocrine status of animals, as well as the level of LH, prolactin and ACTH and changes the content of neurotransmitters in hypothalamus. We consider the changes in sexual function caused by Vilon not relate to change in one parameter only, but are mediated by a set of neuroendocrine and neuromediatorial factors. Significant decrease in prolactin content in blood is worthy of notice, as age-related hypersecretion of this hormone is one of the main factors leading to age-related sexual function decline.
Study Information
pubmed
2006