[The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.].
Ivko. O M OM; Drobintseva. A O AO; Leont'eva. D O DO; Kvetnoy. I M IM; Polyakova. V O VO; Linkova. N S NS
Key Findings
- Both AEDG and KE increased mitochondrial staining by about 1.5‑fold in senescent pineal or thymic cells
- Both peptides reduced the age‑related rise in ribosomal protein L7A (22% for AEDG in pineal cells, 15% for KE in thymic cells)
- The benefits appeared tissue‑specific: AEDG acted mainly on pineal cells, KE on thymic cells
Practical Outcomes
- The results hint that epitalon and vilon might help maintain mitochondrial health in certain tissues, but because the data are limited to in‑vitro experiments, they don’t translate into clear dosing or usage guidelines for biohackers yet. More human studies are needed before these peptides can be recommended for longevity protocols.
Summary
A lab study found that two peptides, epitalon (AEDG) and vilon (KE), can improve mitochondrial markers and lower a ribosomal protein that rises with cell aging in pineal and thymus cells grown in dishes. The effects were modest and only shown in cell cultures, not in people, and no dosing or safety info was provided.
Abstract
It was verified new molecular targets of geroprotective activity of AEDG (epitalon) and KE (vilon) peptides by the method of confocal laser scanning microscopy. It was shown that the MitoTracker Red mitochondries staining decreased and L7A ribosomal protein synthesis compensatory increased during pineal and thymic cell senescence in vitro. AEDG peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining and decreases on 22% the expression of ribosomal protein L7A in cultures of human pineal gland cells during its senescence. KE peptide increases in 1,5 times the square of MitoTracker Red mitochondries staining and decreases on 15% the expression of ribosomal protein L7A in cultures of human thymic cells during its senescence. The square of MitoTracker Red mitochondries staining decreases and the expression of L7A ribosomal protein compensatory increases during pineal gland and thymic cells senescence. We can suppose that AEDG and KE peptides have a tissue-specific effect that normalizes the functions of mitochondria and ribosomes of pinealocytes and thymocytes.
Study Information
pubmed
2020