Effect of vilon on biological age and lifespan in mice.
Khavinson. V K VK; Anisimov. V N VN; Zavarzina. N Y NY; Zabezhinskii. M A MA; Zimina. O A OA; Popovich. I G IG; Shtylik. A V AV; Malinin. V V VV; Morozov. V G VG
Key Findings
- Sub‑cutaneous vilon increased physical activity and endurance in female CBA mice.
- Lifespan was extended and spontaneous tumors were reduced in treated mice.
- No adverse developmental effects or changes in estrous function or free‑radical processes were observed.
Practical Outcomes
- The study suggests vilon could be a safe, long‑term geroprotective agent in mice, but there is no human data, dosing guidance, or delivery method for people. Biohackers should view this as early‑stage evidence that may warrant further research rather than a ready‑to‑use protocol.
Summary
In a mouse study, a peptide called vilon (a short Lys-Glu chain) given under the skin to middle‑aged female mice made them more active, improved endurance, lowered their body temperature, extended their lifespan and reduced tumor formation, without obvious side effects. It didn’t change reproductive cycles or antioxidant markers.
Abstract
Subcutaneous administration of vilon (Lys-Glu) to female CBA mice starting from the 6th month of life increased physical activity and endurance, decreased body temperature, prolonged the lifespan, and prevented the development of spontaneous neoplasms. Vilon had no effect on age-related changes of estrous function and free radical processes. Long-term administration of vilon caused no unfavourable effects on animal development. The obtained results show safety of chronic vilon administration and allow to use this preparation for geroprotection and prophylaxis of age pathology.
Study Information
pubmed
2000
10.1007/bf02682106