Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages.
Khavinson. V K VK; Timofeeva. N M NM; Malinin. V V VV; Egorova. V V VV; Nikitina. A A AA
Key Findings
- Oral vilon increased activity of invertase, maltase, alkaline phosphatase, amino‑ and dipeptidases in the gut.
- The enzyme boost was strongest in 11‑month‑old rats, reducing the usual age‑related decline.
- Both male and female rats showed the effect, suggesting a general benefit across sexes.
Practical Outcomes
- For biohackers interested in gut health, vilon could be a candidate supplement to support digestive enzyme function, especially as you get older. However, the evidence is limited to rats, the effective dose isn’t known, and human safety data are lacking, so any use should be experimental and cautious.
Summary
Giving rats a small peptide called vilon (Lys‑Glu) by mouth boosted the activity of several digestive enzymes, especially in the older 11‑month‑old rats, making their gut function more like younger animals.
Abstract
Peroral administration of Vilon (Lys-Glu) to male and female Wistar rats aging 3 and 11 months changed activity of digestive enzymes (invertase, maltase, alkaline phosphatase, and amino- and dipeptidases) in various portions of the gastrointestinal tract. The increase in enzyme activity was most pronounced in 11-month-old animals, which diminished differences between rats of various ages. Our results indicate that Vilon produces positive effects on digestive enzyme activity during aging.
Study Information
pubmed
2001
10.1023/a:1012319122696