Menu
Submit Data
Peptide Database
Results
No peptides found
Featured

Use search to browse all 100+ peptides

Back to Studies

Vilon

KE, L-Lys-L-Glu, lysylglutamic acid

Quick Stats
Studies 40
Trials 100
Overview Studies Clinical Trials
Score 2
2017 pubmed

[Effect of combined application of ozone therapy and gravitational therapy on the remote results of complex treatment of geriatric patients].

Fridman. N V NV; Linkova. N S NS; Polyakova. V O VO; Drobintseva. A O AO; Тrofimova. S V SV; Kvetnoy. I M IM; Khavinson. V Kh VK

View Original Source

Key Findings

  • KE dipeptide (Lys‑Glu) increased collagen type I expression area in "old" fibroblast cultures by 83%.
  • KE dipeptide raised sirtuin‑6 expression area by 1.6Ă— in "young" fibroblasts.
  • KE dipeptide raised sirtuin‑6 expression area by 2.6Ă— in "old" fibroblasts.

Practical Outcomes

  • For biohackers, the data hint that topical products containing the KE dipeptide might improve skin collagen and anti‑aging markers, but there’s no human dosing or safety information yet. Until clinical trials confirm these effects, the peptide is best viewed as a promising ingredient to watch rather than a ready‑to‑use protocol.

Summary

A lab study found that a short peptide called KE (Lys‑Glu, also known as Vilon) can boost two important skin‑cell proteins: collagen I and sirtuin‑6. In old skin cells, the peptide raised collagen levels by about 83%, and it increased sirtuin‑6 by 1.6‑fold in young cells and 2.6‑fold in old cells. This suggests the peptide helps skin cells stay more youthful in a dish, but the work was done in cell cultures, not on real people.

Abstract

Skin aging is one of the topical issues in modern gerontocosmetology. Application of cosmetic products with short peptides is a promising measure for retardation of skin aging. This research is aimed at investigation of KE (Lys-Glu, Vilon) dipeptide influence on the expression of markers of aging in human skin fibroblasts in vitro. Collagen type I and sirtuin-6 expression in «young» and «old» skin cell fibroblasts cultures was studied using immunofluorescence confocal microscopy method. The areas of expression of collagen type I and sirtuin-6 are known to decrease in skin fibroblasts with aging by 3,5 and 3,6 times accordingly. KE dipeptide increases collagen type I expression area in «old» skin fibroblasts cultures by 83%. KE dipeptide increases expression area of sirtuin-6 in «young» and «old» skin fibroblasts cultures by 1,6 and 2,6 times correspondingly. Thus, KE dipeptide promotes functional activity of skin fibroblasts and inhibits their aging.

Study Information

Provider

pubmed

Year

2017