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Argireline, Acetyl Hexapeptide-8
A synthetic hexapeptide that mimics SNAP-25 to inhibit SNARE complex formation, reducing neurotransmitter release and facial muscle contractions for anti-wrinkle effects.
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Topical
5-10% in formulation, twice daily
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Topical (Iontophoretic)
Variable, research setting
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How It Works: Acetyl-Hexapeptide-3 acts as a topical alternative to botulinum toxin by mimicking the N-terminal end of SNAP-25, disrupting the SNARE complex to inhibit acetylcholine release and relax facial muscles, thereby reducing wrinkles.
Martin. Bianca Aparecida BA; Viegas. Juliana J; Dalmolin. Luciana Facco LF; Sant...
Researchers built a tiny 3‑D skin model that includes nerve cells and showed that a peptide called acetyl‑hexapeptide‑3 (often sold as Argireline) can get through the outer skin layer, gather around the nerves, and trigger several skin‑health benefits.
Edison. Brenda L BL; Parsa. Ramine R; Dufort. Marisa M; Tierney. Neena K NK; Gre...
Lupin. Mark M; Bjerring. Peter P; Andriessen. Anneke A; Chantrey. Jonquille J; F...
A small group of doctors tried a skin cream that contains a peptide called acetyl‑hexapeptide‑8 (along with other ingredients) together with Botox injections. They reported that the combo made skin look brighter and reduced fine lines and wrinkles more than Botox alone.