INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections.
Lupin. Mark M; Bjerring. Peter P; Andriessen. Anneke A; Chantrey. Jonquille J; Fabi. Sabrina Guillen SG; Liew. Steven S; McDonald. Cara C; Xiaolei. Qin Q; White. Stacy S
Key Findings
- The topical serum (2% acetyl‑hexapeptide‑8, plus other actives) was used twice daily alongside Botox injections.
- Clinicians observed improved skin radiance, fewer fine lines, and reduced wrinkles in the treated patients.
- The authors suggest the serum works synergistically with Botox by stimulating multiple skin‑health biomarkers.
Practical Outcomes
- For people interested in anti‑aging skin care, adding a peptide‑rich serum like this to a Botox regimen may give a modest extra boost in brightness and wrinkle reduction. However, the evidence comes from a very small, non‑controlled case series, so results may vary and the benefit is not guaranteed.
Summary
A small group of doctors tried a skin cream that contains a peptide called acetyl‑hexapeptide‑8 (along with other ingredients) together with Botox injections. They reported that the combo made skin look brighter and reduced fine lines and wrinkles more than Botox alone.
Abstract
We evaluated real-life experiences of a topical neuro-peptide serum containing 2% acetyl hexapeptide-8, 2% dipeptide diaminobutyroyl, 5% polyhydroxy acids (PHA), 5% niacinamide, and 1% laminaria extract (topical neuro-peptide serum [TNP-serum]). The TNP-serum works synergistically by stimulating 9 key skin biomarkers to reduce wrinkles and produce a skin-brightening effect. Here, we highlight the real-life experiences of 5 dermatologists and 2 surgeons, using an integrated skincare regimen consisting of botulinum toxin type-A (BTX-A) injection in conjunction with twice daily TNP-serum. Real-world cases provide evidence for combination treatments that may be used in cosmetic dermatology to improve patient outcomes and satisfaction. TNP-serum appears to complement BTX-A injections to improve radiance, reduce fine lines, and reduce wrinkles in diverse patients. Incorporating TNP-serum into integrated skincare regimens may offer an additive effect to BTX-A injections and, ultimately, optimize patient results. J Drugs Dermatol. 2024;23:11(Suppl 2):s3-14.
Study Information
pubmed
2024
2024-11-01T00:00:00.000Z