Combination Tripeptide/Hexapeptide Serum with 1540 nm Nonablative Fractional Laser for the Treatment of Striae Distensae: A Pilot Study.
McGuinn. Kathleen P KP; Ross. Nicholas A NA; Wang. Jordan V JV; Saedi. Nazanin N
Key Findings
- All participants reported feeling their stretch marks improved when the peptide serum was used with the laser.
- Objective measurements showed greater improvement in skin texture compared to laser alone.
- The combined treatment lowered the rate of post‑inflammatory hyperpigmentation.
Practical Outcomes
- For DIY skin‑care or anti‑aging protocols, adding a serum with acetyl‑hexapeptide‑3 (and a supporting tripeptide) around the time of a 1540 nm non‑ablative fractional laser may boost results and reduce dark‑spot side effects. However, the evidence comes from only ten subjects, so users should treat it as a promising hint rather than a proven standard.
Summary
A small pilot study (10 people) found that using a skin serum containing a tripeptide and acetyl‑hexapeptide‑3 together with a 1540 nm non‑ablative fractional laser made stretch marks look better, caused less post‑laser dark spots, and made patients happier with the results.
Abstract
Striae distensae (SD) are associated with negative psychosocial effects. Improvements have been shown with non-ablative fractional lasers (NAFL). Topical peptides have also been effective in cutaneous rejuvenation; however, no studies have examined combination therapy for striae. Our study evaluated the efficacy and safety of a peri-procedural tripeptide/hexapeptide serum as an adjunct to 1540 nm NAFL for the treatment of SD in 10 patients. All patients reported subjective improvement. The addition of tripeptide/hexapep-tide serum increased the objective improvement, reduced the incidence of post-inflammatory hyperpigmentation, and increased patient satisfaction.
Study Information
pubmed
2020
2020-12-01T00:00:00.000Z