Some aspects of the effects of PL-10.1.AK-15 on the gastrointestinal tract.
Erceg. D D; Simicevic. V N VN; Kolega. M M; Dohoczky. C C
Key Findings
- PL-10.1.AK-15 did not affect gastric acid secretion in male Wistar rats.
- PL-10.1.AK-15 did not affect gastrointestinal motility in male NMRI mice.
- The lack of effect was consistent across low, medium, and high doses (3‑100 µg/kg).
Practical Outcomes
- For biohackers looking to use BPC‑157 to boost stomach acid or improve gut movement, this study suggests those specific benefits are unlikely at the tested doses. It provides safety‑type data that the peptide doesn’t disrupt these functions, but it also offers no actionable protocol for enhancing GI performance.
Summary
The study tested a peptide called PL-10.1.AK-15 (also known as BPC‑157) in rats and mice to see if it changes stomach acid production or how fast the gut moves. Across three doses (3, 10, and 100 µg per kg), the peptide didn’t alter either stomach acid or gut motility.
Abstract
PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointestinal motility. Gastric acid secretion was assessed in male Wistar rats using a modified method of Shay, while gastrointestinal motility was assessed in male NMRI mice by charcoal propulsion. PL-10.1.AK-15 was given in three different doses (3, 10 and 100 micrograms/kg body weight) in accordance with the experimental protocol. The results of these experiments indicate that PL-10.1.AK-15 in the investigated doses had no influence on gastric acid secretion or gastrointestinal motility.
Study Information
pubmed
1997
10.1016/s0928-4257(97)89481-8