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BPC-157

Body Protection Compound-157, PL-14736, Pentadecapeptide BPC 157

Quick Stats
Studies 196
Trials 1
Overview Studies Clinical Trials
Score 3
1997 pubmed

Evidence for direct cellular protective effect of PL-10 substances (synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells.

Bódis. B B; Karádi. O O; Németh. P P; Dohoczky. C C; Kolega. M M; Mózsik. G G

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Key Findings

  • The PL-10 substances were not toxic to either gastric or myeloma cells.
  • Two PL-10 variants significantly reduced ethanol‑induced injury in freshly isolated rat gastric mucosal cells.
  • The protective effect was dose‑dependent with an effective dose (ED50) of about 50 ng/ml and did not occur in mouse myeloma cells.

Practical Outcomes

  • These results suggest that BPC‑157 (or its active fragments) may directly shield stomach lining cells, supporting its use for gut protection. For biohackers, low microgram‑range doses could be explored, but remember the data are from isolated rat cells, not human trials, so further testing is needed before adopting it as a reliable protocol.

Summary

In a lab test, tiny pieces of the BPC-157 molecule (called PL-10 substances) were safe for cells and helped protect rat stomach lining cells from damage caused by alcohol, but they didn’t help a different type of cancer cell. The protection worked at very low concentrations (as low as 50 ng/ml).

Abstract

The direct gastric mucosal cellular effect of four PL-10 substances (a synthesized part of human body protection compound, BPC containing 14 or 15 amino acids) was studied on freshly isolated rat gastric mucosal cells and on a mouse myeloma cell line (Sp2/0-Ag14) in an ethanol-induced cell injury model. The examined substances were not toxic for the cells. Two of them proved to be significantly protective against the direct cellular damaging effect of ethanol (PL 10.1.15AK-3 in 5 microg/ml dose and PL 10.1.AK14-2 dose-dependently, ED50=50 ng/ml) on gastric mucosal cells. This cytoprotective effect was failured on mouse myeloma cells. Based on these results a part of the in vivo protection induced by BPC seems to be a direct cellular protective effect to gastric mucosal cells.

Study Information

Provider

pubmed

Year

1997

DOI

10.1016/s0024-3205(97)00744-3