Dose-dependent protective effect of BPC 157 on capsaicin-induced rhinitis in rats.
Kalogjera. L L; Ries. M M; Baudoin. T T; Ferencic. Z Z; Trotic. R R; Pegan. B B
Key Findings
- BPC‑157 pretreatment (10 µg/kg) blocked mast cell infiltration in the nasal lining 1 hour after capsaicin exposure.
- The same dose significantly reduced polymorphonuclear leukocyte (a type of white blood cell) infiltration.
- A dose‑dependent effect was only seen for leukocyte infiltration at the 12‑hour time point.
Practical Outcomes
- The study hints that BPC‑157 may have anti‑inflammatory properties in the nasal passages, which could be relevant for conditions like allergic rhinitis or irritation from spicy foods. However, the work was done in rats, using doses that don’t directly translate to humans, so no concrete dosing protocol can be recommended yet. Biohackers should view this as early, supportive evidence rather than a ready‑to‑use treatment.
Summary
In a rat study, giving the peptide BPC‑157 before exposing the nose to capsaicin (the spicy component of chili peppers) reduced early signs of inflammation, especially the arrival of certain immune cells. The higher dose (10 µg per kg) was more effective at lowering white‑blood‑cell infiltration later on.
Abstract
Protection of BPC 157 on capsaicin-induced rhinitis was studied in Wistar rats for its effect on mastocyte infiltration, degranulation and inflammatory cell infiltration. Animals were pretreated with 10 microg/kg, 10 ng/kg or 2 ml saline i.p. and capsaicin (0.05 ml/nostril of 1750 nmol/l sol.) was applied intranasally. They were then euthanized at 1, 3 and 12 h after capsaicin provocation. Nasal mucosa was analyzed and scored for mastocyte infiltration, degranulation and inflammatory cell infiltration. BPC 157 pretreatment significantly prevented mastocyte infiltration at 1 h. Polymorphonuclear leukocyte infiltration was significantly reduced in rats pretreated with 10 microg/kg BPC 157. A dose-dependent effect of BPC 157 pretreatment was demonstrated only for polymorphonuclear leukocyte infiltration at 12 h.
Study Information
pubmed
1997
10.1007/bf02439711