Gastric pentadecapeptide BPC 157 promotes corneal epithelial defects healing in rats.
Lazić. Ratimir R; Gabrić. Nikica N; Dekaris. Iva I; Bosnar. Damir D; Boban-Blagaić. Alenka A; Sikirić. Predrag P
Key Findings
- Topical BPC‑157 accelerated corneal epithelial defect healing in rats.
- The healing benefit was dose‑dependent, with nanogram and microgram doses showing significant speed‑up.
- Lesions disappeared by 40‑48 hours with BPC‑157, whereas control eyes still had defects at 48 hours.
Practical Outcomes
- For biohackers, this suggests that BPC‑157 could be explored as a topical eye‑drop for faster corneal wound repair, but the evidence is limited to rats and no human safety or dosing data exist. Any self‑experimentation should be approached with extreme caution and preferably avoided until clinical studies confirm efficacy and safety.
Summary
In a rat study, applying the peptide BPC‑157 directly to the eye helped corneal wounds heal faster than doing nothing. The effect was stronger at higher doses, with the biggest improvements seen at nanogram and microgram concentrations.
Abstract
We evaluated the role of human gastric pentadecapeptide BPC 157 in corneal epithelial defects healing in rats. 48 rats, in 4 groups (N=12). Total debridement of corneal epithelium preformed unilaterally and lesions stained and photographed. Animals medicated as follows: distilled water (control group) or BPC 157 2 pg/ml, 2 ng/ml, 2 microg/ml, 2 drops/rat eye started immediately after injury induction, every 8 hours up to 40 hours (i.e., at 0, 8, 16, 24, 32, 40 h). Lesions were photographed before application or sacrifice (at 48 h). Defect area was analyzed using a special program. Through 48 hour period a steady recovery is noted in controls. Recovery was markedly accelerated in eyes on microg- or ng-topical regimen of BPC 157 (p < 0.05). Of note, unlike control lesion present also after 48 h, these lesions disappeared already following 40 h (microg) or 48 h (ng) post-injury. BPC 157 was shown to be effective in promoting corneal defects healing in rats. Results were dose dependent.
Study Information
pubmed
2005